Cardiac steatosis and arrhythmia
| Project/Area Number |
26461360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Fukui |
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Principal Investigator |
Suzuki Jinya 福井大学, 学術研究院医学系部門(附属病院部), 講師 (20293417)
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| Co-Investigator(Kenkyū-buntansha) |
弘瀬 雅教 岩手医科大学, 薬学部, 教授 (40273081)
高橋 貞夫 福井大学, 医学部, 特別研究員 (50303376)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脂肪滴 / 脂肪毒性 / 脂肪心筋 / 不整脈 / 心房細動 / gap junction / connexin 43 / コネキシン43 / ギャップジャンクション |
|---|
| Outline of Final Research Achievements |
The association of cardiac steatosis and arrhythmia was studied using mouse model of cardiac steatosis. The transgenic (Tg) mice with cardiac-specific overexpression of perilipin (PLIN)2 was generated and analyzed. The Tg mice had 4-fold increased atrial triglyceride content and 3-fold higher incidence of prolonged atrial fibrillation. A gap-junction protein connexin 43 was displaced in atrial cardiomyocytes of Tg mice, and conduction velocity was delayed in the Tg atrium. Thus, cardiac steatosis might lead to arrhythmogenic remodeling of connexin 43.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Pioglitazone prevents tau oligomerization.2016
Author(s)
Hamano T, Shirafuji N, Makino C, Yen SH, Kanaan NM, Ueno A, Suzuki J, Ikawa M, Matsunaga A, Yamamura O, Kuriyama M, Nakamoto Y.
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Journal Title
Biochem Biophys Res Commun
Volume: 478
Issue: 3
Pages: 1035-1042
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] On the top of ARB N/L type Ca channel blocker leads to less elevation of aldosterone.2016
Author(s)
Konoshita T, Kaeriyama S, Urabe M, Nakaya T, Yamada M, Ichikawa M, Yamamoto K, Sato S, Imagawa M, Fujii M, Makino Y, Zenimaru Y, Wakahara S, Suzuki J, Ishizuka T, Nakamura H
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Journal Title
Biosci Rep
Volume: 36
Issue: 5
DOI
Related Report
Peer Reviewed
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[Presentation] Perilipin2過剰発現マウスにおける“脂肪心筋”のlipidome解析2016
Author(s)
佐藤 さつき, 鈴木 仁弥, 中屋隆裕, 山田実夏, 市川麻衣, 山本勝司, 今川美智子, 藤井美紀, 銭丸康夫, 生山祥一郎, 弘瀬 雅教, 高橋貞夫, 此下忠志, 石塚 全
Organizer
第48回 日本動脈硬化学会 総会・学術集会
Place of Presentation
京王プラザホテル（東京都新宿区）
Year and Date
2016-07-14
Related Report
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[Presentation] DulaglutideがPerilipin2過剰発現マウスの“脂肪心筋”に与える効果2016
Author(s)
鈴木 仁弥, 佐藤 さつき, 中屋隆裕, 山田実夏, 市川麻衣, 山本勝司, 今川美智子, 藤井美紀, 銭丸康夫, 生山祥一郎, 弘瀬 雅教, 高橋貞夫, 此下忠志, 石塚 全
Organizer
第48回 日本動脈硬化学会 総会・学術集会
Place of Presentation
京王プラザホテル（東京都新宿区）
Year and Date
2016-07-14
Related Report
-
[Presentation] 心筋特異的Perilipin2過剰発現マウスにおける“脂肪心筋”のlipidome解析2016
Author(s)
佐藤 さつき, 鈴木 仁弥, 中屋隆裕, 山田実夏, 市川麻衣, 山本勝司, 今川美智子, 藤井美紀, 銭丸康夫, 生山祥一郎, 弘瀬 雅教, 高橋貞夫, 石塚 全, 此下忠志
Organizer
第59回日本糖尿病学会年次学術集会
Place of Presentation
国立京都国際会館（京都府京都市）
Year and Date
2016-05-19
Related Report
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[Presentation] DulaglutideがPerilipin 2過剰発現による“脂肪心筋”に与える影響2016
Author(s)
鈴木 仁弥, 佐藤 さつき, 中屋隆裕, 山田実夏, 市川麻衣, 山本勝司, 今川美智子, 藤井美紀, 銭丸康夫, 生山祥一郎, 弘瀬 雅教, 高橋貞夫, 石塚 全, 此下忠志
Organizer
第59回日本糖尿病学会年次学術集
Place of Presentation
国立京都国際会館（京都府京都市）
Year and Date
2016-05-19
Related Report
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