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The impact of ACAM/CLMP on the adipocytes differentiation and obesity through the primary ciliary machinery

Research Project

Project/Area Number 26461362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionOkayama University

Principal Investigator

Murakami Kazutoshi  岡山大学, 医学部, 客員研究員 (40620753)

Research Collaborator WADA JUN  岡山大学, 大学院医歯薬学総合研究科, 教授
EGUCHI JUN  岡山大学, 大学病院, 講師
NAKATSUKA ATSUKO  岡山大学, 大学病院, 助教
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脂肪細胞 / メタボリックシンドローム / 肥満症 / 膜蛋白 / 接着分子 / アドヘレンスジャンクション / アクチン / アドへレンスジャンクション / 肥満 / 一次繊毛
Outline of Final Research Achievements

The excess of lipid accumulation and hypertrophy of adipocytes induces the abnormality of secretion of adipokines and hormones from adipocytes and causes metabolic syndrome and diabetes. We identified ACAM in 2005 from the visceral fat tissue of obese rats. It is a cell adhesion molecule responsible for the homophilic adhesion of the cells. In the transgemic mice overexpressing ACAM in adipocytes fed with a high fat and high sucrose diet were protected from the onset of obesity and diabetes. In transgemnic mice, ACAM is abundantly expressed on plasma membrane of mature adipocytes and associated with formation of Phalloidin-positive polymerized form of cortical actin (F-actin). By electron microscopy, the structure of zonula adherens was formed at interphase of adipocytes. The adhesion of adipocytes and formation of cortical actin prevent the adipocyte hypertrophy and development of obesity and diabetes.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Antiobesity action of ACAM by modulating the dynamics of cell adhesion and actin polymerization in adipocytes.2016

    • Author(s)
      Murakami K, Eguchi J, Hida K, Nakatsuka A, Katayama A, Sakurai M, Choshi H, Furutani M, Ogawa D, Takei K, Otsuka F, Wada J
    • Journal Title

      Diabetes

      Volume: 65(5) Issue: 5 Pages: 1255-1267

    • DOI

      10.2337/db15-1304

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitis.2016

    • Author(s)
      Nakatsuka A, Matsuyama M, Yamaguchi S, Katayama A, Eguchi J, Murakami K, Teshigawara S, Ogawa D, Wada N, Yasunaka T, Ikeda F, Takaki A, Watanabe E, Wada J.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 21721-21721

    • DOI

      10.1038/srep21721

    • NAID

      120005728628

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Beneficial impact of Gpnmb and its significance as a biomarker in nonalcoholic steatohepatitis.2015

    • Author(s)
      Katayama A, Nakatsuka A, Eguchi J, Murakami K, Teshigawara S, Kanzaki M, Nunoue T, Hida K, Wada N, Yasunaka T, Ikeda F, Takaki A, Yamamoto K, Kiyonari H, Makino H, Wada J.
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 16920-16920

    • DOI

      10.1038/srep16920

    • NAID

      120005697274

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes.2015

    • Author(s)
      Wang Y, Katayama A, Terami T, Han X, Nunoue T, Zhang D, Teshigawara S, Eguchi J, Nakatsuka A, Murakami K, Ogawa D, Furuta Y, Makino H, Wada J.
    • Journal Title

      Metabolism

      Volume: 未定 Issue: 6 Pages: 677-88

    • DOI

      10.1016/j.metabol.2015.02.004

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of Circulating miR-101, miR-375 and miR-802 as Biomarkers for Type 2 Diabetes.2015

    • Author(s)
      Higuchi C, Nakatsuka A, Eguchi J, Teshigawara S, Kanzaki M, Katayama A, Yamaguchi S, Takahashi N, Murakami K, Ogawa D, Sasaki S, Makino H, Wada J.
    • Journal Title

      Metabolism

      Volume: 64(4) Issue: 4 Pages: 489-97

    • DOI

      10.1016/j.metabol.2014.12.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] The anti-obesity action of ACAM by modulating the dynamics of cell adhesion and actin polymerization in adipocytes.2015

    • Author(s)
      Kazutoshi Murakami, Jun Eguchi, Atsuko Nakatsuka, Tomokazu Nunoue, Satoshi Yamaguchi and Jun Wada
    • Organizer
      75th American Diabetes Association
    • Place of Presentation
      Boston(アメリカ合衆国)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脂肪細胞における接着とアクチン重合を介したACAMの抗肥満作用2014

    • Author(s)
      村上和敏、和田淳、江口潤、中司敦子、槇野博史
    • Organizer
      第35回 日本肥満学会
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎)
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] The anti-obesity action of ACAM by modulating the dynamics of cell adhesion and actin polymerization in adipocytes.2014

    • Author(s)
      村上和敏、和田淳、江口潤、中司敦子、槇野博史
    • Organizer
      インスリン抵抗性とメタボリックシンドローム研究会
    • Place of Presentation
      ハイアットリージェンシー(東京)
    • Year and Date
      2014-07-05 – 2014-07-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 脂肪細胞における接着とアクチン重合を介したACAMの抗肥満作用2014

    • Author(s)
      村上和敏
    • Organizer
      第4回 Okayama Young Investigator’s Seminar
    • Place of Presentation
      岡山大学(岡山)
    • Year and Date
      2014-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] ACAM (adipocyte adhesion molecule) /CLMPの一次繊毛機能を介した脂肪細胞分化と肥満症における意義2014

    • Author(s)
      村上和敏、和田淳、江口潤、中司敦子、槇野博史
    • Organizer
      第57回 日本糖尿病学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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