| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Apop gene was originally cloned as a gene expressed in the mouse atherosclerotic plaques. Apop gene encodes a protein localized in the mitochondria of cells. The function of Apop was unclear, however, our research revealed that Apop is implicated in the regulation of mitochondrial function. Apop gene-deficient mouse showed lowered cholesterol level and reduced visceral fat tissue, suggesting the improved metabolism of fat. This study clarified that Apop gene plays an important role in the development of metabolic syndrome.
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