Prevention of Metabolic syndrome by Apop gene regulation

• Project/Area Number: 26461364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: National Institute of Fitness and Sports in Kanoya (2016-2017); Kumamoto University (2014-2015)
• Principal Investigator: Yasuda Osamu 鹿屋体育大学, スポーツ生命科学系, 教授 (00372615)
• Co-Investigator(Kenkyū-buntansha): 樂木 宏実 大阪大学, 医学系研究科, 教授 (20252679) ; 福尾 惠介 武庫川女子大学, 生活環境学部, 教授 (40156758)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ミトコンドリア / メタボリック症候群

Outline of Final Research Achievements

Apop gene was originally cloned as a gene expressed in the mouse atherosclerotic plaques. Apop gene encodes a protein localized in the mitochondria of cells. The function of Apop was unclear, however, our research revealed that Apop is implicated in the regulation of mitochondrial function. Apop gene-deficient mouse showed lowered cholesterol level and reduced visceral fat tissue, suggesting the improved metabolism of fat. This study clarified that Apop gene plays an important role in the development of metabolic syndrome.

Research Products

• [Journal Article] Cardiovascular and renal protective role of angiotensin blockade in hypertension with advanced CKD: a subgroup analysis of ATTEMPT-CVD randomized trial (2018)
  • Author(s): Kim-Mitsuyama Shokei、Soejima Hirofumi、Yasuda Osamu、Node Koichi、Jinnouchi Hideaki、Yamamoto Eiichiro、Sekigami Taiji、Ogawa Hisao、Matsui Kunihiko
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 3150-3150
  • DOI: 10.1038/s41598-018-20874-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 腎機能と筋肉量の相関 (2018)
  • Author(s): 安田 修、藤井 康成、小牧 梨沙、添嶋 裕嗣
  • Journal Title: Campus Health Volume: 55
  • NAID: 40022282676
  • Peer Reviewed
• [Journal Article] Kumamoto Earthquake and health issues of the elderly (2017)
  • Author(s): Yasuda O、Ikeda Y、Ohishi M
  • Journal Title: Nihon Ronen Igakkai Zasshi Volume: 54 Pages: 120-124
  • NAID: 130005691003
  • Open Access
• [Journal Article] A trial of telmisartan prevention of cardiovascular diseases (ATTEMPT-CVD): Biomarker study (2016)
  • Author(s): Ogawa H, Soejima H, Matsui K, Kim-Mitsuyama S, Yasuda O, Node K, Yamamuro M, Yamamoto E, Kataoka K, Jinnouchi H, Sekigami T
  • Journal Title: Eur J Prev Cardiol Volume: 23 Issue: 9 Pages: 913-921
  • DOI: 10.1177/2047487315603221
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A trial of telmisartan prevention of cardiovascular diseases (ATTEMPT-CVD): Biomarker study (2015)
  • Author(s): Ogawa H, Soejima H, Matsui K, Kim-Mitsuyama S, Yasuda O, Node K, Yamamuro M, Yamamoto E, Kataoka K, Jinnouchi H, Sekigami T; ATTEMPT-CVD investigators
  • Journal Title: Eur J Prev Cardiol Volume: Ahead of print
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Sirt7 Contributes to Myocardial Tissue Repair by Maintaining Transforming Growth Factor-β Signaling Pathway (2015)
  • Author(s): Araki S, Izumiya Y, Rokutanda T, Ianni A, Hanatani S, Kimura Y, Onoue Y, Senokuchi T, Yoshizawa T, Yasuda O, Koitabashi N, Kurabayashi M, Braun T, Bober E, Yamagata K, Ogawa H
  • Journal Title: Circulation Volume: 132(12) Issue: 12 Pages: 1081-1093
  • DOI: 10.1161/circulationaha.114.014821
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] ASK1 is involved in cognitive impairment caused by long-term high-fat diet feeding in mice (2015)
  • Author(s): Toyama K, Koibuchi N, Hasegawa Y, Uekawa K, Yasuda O, Sueta D, Nakagawa T, Ma M, Kusaka H, Lin B, Ogawa H, Ichijo H, Kim-Mitsuyama S
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 10844-10844
  • DOI: 10.1038/srep10844
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Telmisartan enhances mitochondrial activity and alters cellular functions in human coronary artery endothelial cells via AMP-activated protein kinase pathway (2015)
  • Author(s): Kurokawa H, Sugiyama S, Nozaki T, Sugamura K, Toyama K, Matsubara J, Fujisue K, Ohba K, Maeda H, Konishi M, Akiyama E, Sumida H, Izumiya Y, Yasuda O, Kim-Mitsuyama S, Ogawa H
  • Journal Title: Atherosclerosis Volume: 239(2) Issue: 2 Pages: 375-385
  • DOI: 10.1016/j.atherosclerosis.2015.01.037
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Tissue Inhibitor of Metalloproteinase-3 Knockout Mice Exhibit Enhanced Energy Expenditure through Thermogenesis (2014)
  • Author(s): Hanaoka Y, Yasuda O, Soejima H, Miyata K, Yamamoto E, Izumiya Y, Maeda N, Ohishi M, Rakugi H, Oike Y, Kim-Mitsuyama S, Ogawa H
  • Journal Title: PLoS One Volume: 9 Issue: 4 Pages: e94930-e94930
  • DOI: 10.1371/journal.pone.0094930
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between extent of myocardial fibrosis assessed by cardiac magnetic resonance and cardiac troponin T release in patients with nonischemic heart failure. (2014)
  • Author(s): Takashio S, Yamamuro M, Uemura T, Utsunomiya D, Morita K, Izumiya Y, Sugiyama S, Kojima S, Yamamoto E, Tsujita K, Tanaka T, Tayama S, Kaikita K, Hokimoto S, Yasuda O, Yamashita Y, Ogawa H.
  • Journal Title: American Journal of Cardiology Volume: 113 Issue: 10 Pages: 1697-1704
  • DOI: 10.1016/j.amjcard.2014.02.029
  • Peer Reviewed / Open Access
• [Presentation] Significance of Mitral Regurgitation after Aortic Valve Replacement in Severe Aortic Stenosis Patients (2018)
  • Author(s): Yasuda H、Yasuda O、Tsujita K
  • Organizer: The 82nd Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research
• [Presentation] Analysis of Concomitant Mitral Regurgitation in Severe Aortic Stenosis Patients (2017)
  • Author(s): H Yasuda, O Yasuda, K Tsujita
  • Organizer: The 81st Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: 石川県立音楽堂（石川県・金沢市）
  • Year and Date: 2017-03-17
  • Int'l Joint Research
• [Presentation] 若年アスリートにおける筋肉量と腎機能に関する解析 (2017)
  • Author(s): 安田 修、藤井 康成、小牧 梨沙、添嶋 裕嗣
  • Organizer: 第55回全国大学保健管理研究集会
• [Presentation] 歯周病菌はヒト動脈内に認められる (2017)
  • Author(s): 副島 弘文、安田 修、中山 秀樹、辻田 賢一、小川 久雄
  • Organizer: 第65回日本心臓病学会学術集会
• [Presentation] Apop発現抑制と血管内皮細胞の老化 (2016)
  • Author(s): 安田 修
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 石川県立音楽堂（石川県・金沢市）
  • Year and Date: 2016-06-08
• [Presentation] Apop遺伝子を標的とした抗老化研究 (2016)
  • Author(s): 安田 修
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 石川県立音楽堂（石川県・金沢市）
  • Year and Date: 2016-06-08
  • Invited
• [Presentation] Analysis of Apop Gene Expression in Human Atherosclerotic Tissue (2016)
  • Author(s): Osamu Yasuda, Hirofumi Soejima, Koichi Kaikita, Yohsuke Hanaoka, Hisayo Yasuda, Yuichi Oike, Hisao Ogawa
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂、仙台
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] Apoptogenic Protein is Involved in Endothelial Senescence Induced by High Glucose (2015)
  • Author(s): Osamu Yasuda, Hirofumi Soejima, Keishi Miyata, Hisayo Yasuda, Yuichi Oike, Hisao Ogawa
  • Organizer: American Heart Association
  • Place of Presentation: Orland、US
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Analysis of Apop Gene Expression in Human Atherosclerotic Tissue (2015)
  • Author(s): Osamu Yasuda, Hirofumi Soejima, Koichi Kaikita, Yohsuke Hanaoka, Hisayo Yasuda, Yuichi Oike, Hisao Ogawa
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-24 – 2015-04-26
• [Presentation] Apoptogenic Protein is a Novel Phenotypic Marker of the Contractile Vascular Smooth Muscle Cells (2014)
  • Author(s): Osamu Yasuda, Hirofumi Soejima, Keishi Miyata, Hisayo Yasuda, Hiromi Rakugi, Yuichi Oike, Shoukei-Kim Mitsuyama, Hisao Ogawa
  • Organizer: American Heart Association
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-17 – 2014-11-19