Contribution of KATP channel in PVN oxytocin neurons for food intake regulation.

• Project/Area Number: 26461366
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Fukushima Medical University
• Principal Investigator: Shimomura Kenju 福島県立医科大学, 医学部, 教授 (90636226)
• Co-Investigator(Renkei-kenkyūsha): Maejima Yuko 福島県立医科大学, 医学部 医療エレクトロニクス研究講座 薬理学講座, 准教授 (40438669)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: オキシトシン / KATPチャネル / オレキシン / 脳室傍核 / 過食 / ＫＡＴＰチャネル

Outline of Final Research Achievements

Increase of obesity population is becoming a social problem. In order to solve this problem, elucidation of food intake regulation mechanism in brain is essential. In this study we have focused on KATP channel which is known to be regulated by glucose and influence the neuron activity. We found that KATP channel is indirectly regulating the activity of oxytocin neuron in paraventricular nucleus (PVN) in hypothalamus. Because PVN oxytocin neurons are important for food intake regulation, KATP channel may be a future target for the treatment of obesity.

Research Products

• [Journal Article] Non-alcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men and women (2017)
  • Author(s): Tokita Y, Maejima Y, Shimomura K, Takenoshita S, Ishiyama N, Akuzawa M, Shimomura Y, Nakajima K.
  • Journal Title: Internal Medicine Volume: 56 Pages: 763771-763771
  • NAID: 130005530252
  • Peer Reviewed
• [Journal Article] Orexin action on oxytocin neurons in the paraventricular nucleus of the hypothalamus. (2017)
  • Author(s): Maejima Y, Takahashi S, Takasu K, Takenoshita S, Ueta Y, Shimomura K.
  • Journal Title: Neuroreport Volume: 28 Issue: 6 Pages: 360366-360366
  • DOI: 10.1097/wnr.0000000000000773
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells. (2016)
  • Author(s): Brereton MF, Rohm M, Shimomura K, Holland C, Tornovsky-Babeay S, Dadon D, Iberl M, Chibalina MV, Lee S, Glaser B, Dor Y, Rorsman P, Clark A, Ashcroft FM.
  • Journal Title: Nature Communications Volume: 24 Issue: 1 Pages: 13496-13496
  • DOI: 10.1038/ncomms13496
  • Peer Reviewed / Open Access
• [Journal Article] Islet Insulin Secretion Measurements in the Mouse. (2016)
  • Author(s): Hugill A, Shimomura K, Cox RD
  • Journal Title: Curr Protoc Mouse Biol. Volume: 1 Issue: 3 Pages: 256-271
  • DOI: 10.1002/cpmo.14
  • Peer Reviewed
• [Journal Article] Impact of the Visceral Fat Area Measured by Dual Impedance Method on the Diagnostic Components of Metabolic Diseases in a Middle-aged Japanese Population (2016)
  • Author(s): Sakamaki K, Maejima Y, Tokita Y, Masamura Y, Kumamoto K, Akuzawa M, Nagano N, Nakajima K, Shimomura K, Takenoshita S, Shimomura Y
  • Journal Title: Internal Medicine Volume: 55 Issue: 13 Pages: 1691-1696
  • DOI: 10.2169/internalmedicine.55.6088
  • NAID: 130005161034
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Projection from a single NUCB2/nesfatin-1 neuron in the paraventricular nucleus to different brain regions involved in feeding (2015)
  • Author(s): Majima Y, Kumamoto K, Takenoshita S, Shimomura K.
  • Journal Title: Brain Structure and Function Volume: ahead of print Issue: 9 Pages: 4723-4731
  • DOI: 10.1007/s00429-015-1150-4
  • Peer Reviewed
• [Journal Article] Central action of ELABELA reduces food intake and activates arginine vasopressin and corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. (2015)
  • Author(s): Santoso P, Maejima Y, Kumamoto K, Takenoshita S, Shimomura K.
  • Journal Title: Ｎｅｕｒｏｒｅｐｏｒｔ Volume: 26 Issue: 14 Pages: 820-826
  • DOI: 10.1097/wnr.0000000000000431
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Water intake disorder in a DEND syndrome afflicted patient with R50P mutation (2015)
  • Author(s): Maejima Y, Hasegawa S, Horita S, Kumamoto K, Galbanovskis J, Takenoshita S, Shimomura K.
  • Journal Title: Endocrine Journal Volume: 62 Issue: 4 Pages: 387-392
  • DOI: 10.1507/endocrj.EJ14-0392
  • NAID: 130005066941
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access
• [Journal Article] Nasal oxytocin administration reduce food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. (2015)
  • Author(s): Maejima Y, Rita RS, Santoso P, Aoyama M, Hiraoka Y, Nishimori K, Gantulga D, Shimomura K, Yada T
  • Journal Title: Neuroendocrinology Volume: 101 Issue: 1 Pages: 35-44
  • DOI: 10.1159/000371636
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcute POMC neurons. (2014)
  • Author(s): Maejima Y, Sakuma S, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T
  • Journal Title: FEBS Letter Volume: 588 Issue: 23 Pages: 4404-4412
  • DOI: 10.1016/j.febslet.2014.10.010
  • Peer Reviewed / Open Access
• [Presentation] KATPチャネル異常によるＤＥＮＤ症候群における飲水障害 (2017)
  • Author(s): 下村健寿
  • Organizer: 小児科学会
  • Place of Presentation: 高輪プリンスホテル
  • Year and Date: 2017-04-15