Regulation of macrophage foam cell formation and atherosclerosis by tissue-specific calpains
| Project/Area Number |
26461368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Showa University |
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Principal Investigator |
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| Research Collaborator |
MIYAZAKI Takuro 昭和大学, 医学部生化学講座, 講師 (80398693)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | カルパイン / ピノサイトーシス / マクロファージ / 動脈硬化 / カルパイン６ / CWC22 |
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| Outline of Final Research Achievements |
Calpain-6, a member of calpain superfamily that has no proteolytic activity, was shown to be highly expressed in inflammatory macrophages and interact in the cytoplasm with CWC22, a factor that promotes nuclear translocation of exon-junction complexes, thereby interfering with nuclear translocation of CWC22. Association of CPNA6 with CWC22 led to suppression of mRNA splicing of various genes including Rac1 and acceleration of LDL pinocytosis by macrophages and subsequent development of atherosclerosis in mice.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.2016
Author(s)
Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A
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Journal Title
J Clin Invest
Volume: 126
Issue: 9
Pages: 3417-3432
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells.2015
Author(s)
Miyazaki, T., Taketomi, Y., Saito, Y., Hosono, T., Lei, X.F., Kim-Kaneyama, J.R., Arata, S., Takahashi, H., Murakami, M., and Miyazaki, A.
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Journal Title
Circ. Res.
Volume: 116
Issue: 7
Pages: 1170-1181
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] NADPH oxidase deficiency exacerbates angiotensin II-induced abdominal aortic aneurysms in mice.2014
Author(s)
Kigawa Y, Miyazaki T, Lei XF, Nakamachi T, Oguchi T, Kim-Kaneyama JR, Taniyama M, Tsunawaki S, Shioda S, Miyazaki A
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 34
Issue: 11
Pages: 2413-2420
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Disturbance of pre-mRNA splicing by calpain-6 aggravates macrophage cholesterol deposition in atherosclerotic lesions.2016
Author(s)
Miyazaki T, Tonami K, Hata S, Aiuchi, T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A.
Organizer
第24回日本血管生物医学会学術集会
Place of Presentation
長崎ブリックホール
Year and Date
2016-12-09
Related Report
Invited
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[Presentation] Calpain-6 potentiates pro-atherogenic pinocytosis in macrophages.2016
Author(s)
Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A.
Organizer
19th International vascular biology meeting
Place of Presentation
Sheraton Boston Hotel, Boston, 米国
Year and Date
2016-11-01
Related Report
Int'l Joint Research
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