Molecular basis of the severe ectopic browning transition of adipocytes in novel mice with resistance against obesity and diabetes
Project/Area Number |
26461369
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Toho University |
Principal Investigator |
JIANG Meizi 東邦大学, 医学部, 非常勤研究生 (00624066)
|
Co-Investigator(Renkei-kenkyūsha) |
BUJO Hideaki 東邦大学, 医学部, 教授 (80291300)
|
Research Collaborator |
SHIMIZU Naomi 東邦大学, 医学部, 講師 (30375802)
HIGASHI Morihiko 埼玉医科大学, 医学部, 准教授 (00323395)
Antonio Vidal-Puig University of Cambridge, Addenbrooke's Hospital Metabolic Research Laboratories, 教授
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | LR11 / エネルギー消費 / 褐色細胞 / 機能獲得 / 肥満 / 糖尿病 / 熱代謝 / 褐色分化 / インスリン抵抗性 / ノックアウトマウス / 褐色脂肪 / 可溶性LR11 / 皮下脂肪 |
Outline of Final Research Achievements |
This study was aimed to clarify the mechanism underlying the regulation for the functional transition from white adipocytes to brown adipocytes, and to propose a novel modulation therapy for diabetes and obesity. Cell biological analyses showed that LR11 played an important role as an inhibitor in the functional acquisition of brown adipocytes. Intracellular signal analyses showed that, in the inhibition activity of soluble LR11 for the browning differentiation, LR11 was thought to at least in part inhibit the BMP7-induced signal cascade by the complex formation with the receptor BMPR. Taken together, LR11 was an inhibitor for the functional acquisition of brown adipocytes, and is possibly applied for the novel therapy for obesity and diabetes.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Prognostic impact of circulating soluble LR11 on long-term clinical outcomes in patients with coronary artery disease.2015
Author(s)
Ogita M, Miyauchi K, Kasai T, Tsuboi S, Wada H, Naito R, Konishi H2, Dohi T2, Tamura H2, Okazaki S2, Yanagisawa N, Shimada K, Suwa S, Jiang M, Bujo H, Daida H
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Journal Title
Atherosclerosis
Volume: 244
Pages: 216-221
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.2015
Author(s)
Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T.
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Journal Title
Sci Rep
Volume: 30
Issue: 1
Pages: 17565-17565
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.2015
Author(s)
Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H.
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Journal Title
Nat Commun
Volume: 6
Issue: 1
Pages: 8951-8951
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Circulating soluble LR11, a novel marker of smooth muscle cell proliferation, is enhanced after coronary stenting in response to vascular injury.2014
Author(s)
Ogita M, Miyauchi K, Jiang M, Kasai T, Tsuboi S, Naito R, Konishi H1, Dohi T1, Yokoyama T, Okazaki S, Shimada K, Bujo H, Daida H
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Journal Title
Atherosclerosis.
Volume: 237
Pages: 374-378
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes.2014
Author(s)
Tsukamoto S, Takeuchi M, Kawaguchi T, Togasaki E, Yamazaki A, Sugita Y, Muto T, Sakai S, Takeda Y, Ohwada C, Sakaida E, Shimizu N, Nishii K, Jiang M, Yokote K, Bujo H, Nakaseko C.
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Journal Title
Exp Mol Med.
Volume: -
Issue: 4
Pages: 46-89
DOI
Related Report
Peer Reviewed / Open Access
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