The new function of cave-in-1 in the ABCA1-mediated HDL biogenesis
Project/Area Number |
26461370
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Chubu University |
Principal Investigator |
LU Rui 中部大学, 応用生物学部, 講師 (80381862)
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Co-Investigator(Kenkyū-buntansha) |
横山 信治 中部大学, 応用生物学部, 特任教授 (10142192)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | ABCA1 / caveolin-1 / HDL / ABCG1 |
Outline of Final Research Achievements |
Expression of ATP binding cassette transporter (ABC) A1, a key membrane protein for bio- genesis of high-density lipoprotein (HDL), is regulated not only by its gene transcription but also by its intracellular degradation to modulate plasma HDL concentration. We here undertook investigation of the role of caveolin-1 in the ABCA1- mediated HDL biogenesis in order to understand how cell cholesterol homeostasis is regulated by caveolin-1 function. In this study, we conclude that caveolin-1 enhances internalization and degradation of ABCA1 by its association with ABCA1. Interference of this interaction by probucol oxidative products suppresses ABCA1 degradation and increase HDL biogenesis.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Probucol-Oxidized Products, Spiroquinone and Diphenoquinone, Promote Reverse Cholesterol Transport in Mice2016
Author(s)
Yakushiji E, Ayaori M, Nishida T, Shiotani K, Takiguchi S, Nakaya K, Uto-Kondo H, Ogura M, Sasaki M, Yogo M, Komatsu T, Lu R, Yokoyama S, Ikewaki K
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 36
Issue: 4
Pages: 591-597
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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