Study on the mechanistic basis for the CNP/GC-B-activating therapy for impaired skeletal growth
| Project/Area Number |
26461381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中尾 一祐 京都大学, 医学研究科, 助教 (40599932)
藤井 寿人 京都大学, 医学研究科, 助教 (50537347)
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| Research Collaborator |
Kondo Eri 京都大学, 医学研究科, 研究生
YAMASHITA YUI 京都大学, 医学(系)研究科(研究院), 医員
KANAI YUGO 京都大学, 医学研究科, 大学院生
UEDA YOHEI 京都大学, 医学研究科, 大学院生
HIROTA KEISHO 京都大学, 医学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨伸長 / 内軟骨性骨化 / ナトリウム利尿ペプチド / CNP / 器官培養 / ノックアウトマウス / CNP/GC-B / GC-B |
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| Outline of Final Research Achievements |
Bones in mammals are formed through endochondral ossification, in that cartilaginous anlages are firstly formed and then replaced by calcified bone tissues. Because endochondral ossification is a complicated system, few signaling pathways are known to stimulate bone growth. Recently, we discovered that C-type natriuretic peptide (CNP) and its receptor, guanylyl cyclase-B (GC-B) are potent stimulators of bones formed through endochondral ossification. In the present study, we investigated the physiological mechanism of the effect of CNP/GC-B signaling on endochondral bone growth, in anticipation of future clinical application toward disorders with impaired bone growth.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] C-type natriuretic peptide restores impaired skeletal growth in a murine model of glucocorticoid-induced growth retardation.2016
Author(s)
Ueda Y, Yasoda A, Yamashita Y, Kanai Y, Hirota K, Yamauchi I, Kondo E, Sakane Y, Yamanaka S, Nakao K, Fujii T, Inagaki N.
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Journal Title
Bone.
Volume: 92
Pages: 157-157
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased bone turnover and possible accelerated fracture healing in a murine model with an increased circulating C-type natriuretic peptide2015
Author(s)
Eri Kondo, Akihiro Yasoda, Toshihito Fujii, Kazumasa Nakao, Yui Yamashita, Yoriko Ueda-Sakane, Naotetsu Kanamoto, Masako Miura, Hiroshi Arai, Masashi Mukoyama, Nobuya Inagaki and Kazuwa Nakao
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Journal Title
Endocrinology
Volume: 156
Issue: 7
Pages: 2518-2529
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The local CNP/GC-B system in the growth plate is responsible for physiological endochondral bone growth.2015
Author(s)
Nakao, K., Osawa, K., Yasoda, A., Yamanaka, S., Fujii, T., Kondo, E., Koyama, N., Kanamoto, N., Miura, M., Kuwahara, K., Akiyama, H., Bessho, K., and Nakao, K..
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 1-11
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Congenital myasthenic syndrome in Japan: ethnically unique mutations in muscle nicotinic acetylcholine receptor subunits2015
Author(s)
Azuma Y, Nakata T, Tanaka M, Shen X M, Ito M, Iwata S, Okuno T, Nomura Y, Ando N, Ishigaki K, Ohkawara B, Masuda A, Natsume J, Kojima S, Sokabe M, Ohno K
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Journal Title
Neuromuscul Disord
Volume: 25
Issue: 2
Pages: 60-69
DOI
Related Report
Peer Reviewed
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[Presentation] Osteocrinの骨伸長促進作用の検討2016
Author(s)
金井有吾, 八十田明宏, 森慶太, 高野晴子, 山下唯, 廣田圭昭, 植田洋平, 山内一郎, 上田依利子, 近藤絵里, 藤井寿人, 横井秀基, 稲垣暢也
Organizer
第89回日本内分泌学会学術総会
Place of Presentation
京都国際会館
Related Report
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