| Project/Area Number |
26461381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中尾 一祐 京都大学, 医学研究科, 助教 (40599932)
藤井 寿人 京都大学, 医学研究科, 助教 (50537347)
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| Research Collaborator |
Kondo Eri 京都大学, 医学研究科, 研究生
YAMASHITA YUI 京都大学, 医学(系)研究科(研究院), 医員
KANAI YUGO 京都大学, 医学研究科, 大学院生
UEDA YOHEI 京都大学, 医学研究科, 大学院生
HIROTA KEISHO 京都大学, 医学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨伸長 / 内軟骨性骨化 / ナトリウム利尿ペプチド / CNP / 器官培養 / ノックアウトマウス / CNP/GC-B / GC-B |
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| Outline of Final Research Achievements |
Bones in mammals are formed through endochondral ossification, in that cartilaginous anlages are firstly formed and then replaced by calcified bone tissues. Because endochondral ossification is a complicated system, few signaling pathways are known to stimulate bone growth. Recently, we discovered that C-type natriuretic peptide (CNP) and its receptor, guanylyl cyclase-B (GC-B) are potent stimulators of bones formed through endochondral ossification. In the present study, we investigated the physiological mechanism of the effect of CNP/GC-B signaling on endochondral bone growth, in anticipation of future clinical application toward disorders with impaired bone growth.
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