| Project/Area Number |
26461383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHARA Naotada 久留米大学, 分子生命科学, 教授 (10325516)
YAMADA Yuma 北海道大学, 薬学研究院, 助教 (60451431)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ミトコンドリア / 糖尿病 / 小胞体ストレス / DRP1 / DRP１ / ミトコンドリアダイナミクス / Drp1 / Mff / 糖代謝 / メタボリックシンドローム / オルガネラネットワーク / FGF21 / 肥満 |
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| Outline of Final Research Achievements |
Mitochondria are highly dynamic organelles that frequently fuse and divide in response to cellular energy demands. In an excessive energy state such as a high fat diet, the organelle network between Mt and ER is impaired, followed by the induction of ER stress. As a result, FGF21 is secreted from the liver by activation of PERK-eIF2a-ATF4 pathway, and energy expenditure is accelerated in the peripheral organs such as skeletal muscle and adipose tissue. In other words, mitochondrial dynamics-ER stress-FGF21 axis function as a biological defense system for energy excess. Therefore, mitochondrial dynamics is a therapeutic target for the obese diabetes.
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