| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Fatty acid-binding protein 4 (FABP4) is expressed in adipocytes and macrophages. Here we investigated the mechanism of secretion of FABP4 and its functions. FABP4 was secreted from adipocytes despite of the lack of signal peptides. Treatment with FABP4 promoted inflammation in a dose-dependent manner, leading to the development of atherosclerosis. FABP4 concentration was independently assocciated with not only insulin resistance and atherosclerosis but also cardiac diastolic dysfunction and PCSK9 level. Several drugs, including angiotensin II receptor blockers, a DPP-4 inhibitor, and EPA/DHA, significantly decreased FABP4 levels. Furthermore, ectopic expression of FABP4 was observed in wire-injured endothelial cells, which was associated with neointima formation.
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