Epitope-specific therapy for Graves' disease with immune-modulating peptides and siglec ligands
| Project/Area Number |
26461385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Inaba Hidefumi 和歌山県立医科大学, 医学部, 講師 (70447770)
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| Co-Investigator(Kenkyū-buntansha) |
赤水 尚史 和歌山県立医科大学, 医学部, 教授 (20231813)
西 理宏 和歌山県立医科大学, 医学部, 准教授 (90228148)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | バセドウ病 / TSH受容体 / HLA / T細胞 / HLA-DR / TSHR / Siglec |
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| Outline of Final Research Achievements |
The aim of this study is 1) to elucidate epitope presentation in Graves’ disease (GD), and 2) to establish epitope specific therapy for GD. We have reported that human TSH receptor (AA78-94) was an important epitope. Therapeutic role of the mutant human TSH receptor peptide: 37m, was evaluated in this study. GD model of HLA-DR3 transgenic mice was treated with 37m. The thyrotoxicosis was improved, TRAb production was suppressed, and proportion of regulatory T-cells in the spleen was increased. Therefore, immune-regulatory effects of 37m were observed.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] A novel immunopathological association of IgG4-RD and vasculitis with Hashimoto's thyroiditis.2016
Author(s)
Minamino H, Inaba H, Ariyasu H, Furuta H, Nishi M, Yoshimasu T, Nishikawa A, Nakanishi M, Tsuchihashi S, Kojima F, Murata S, Inoue G, Akamizu T.
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Journal Title
Endocrinol Diabetes Metab Case Rep
Volume: 2016
Pages: 160004-160004
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinicopathological features of Riedel’s thyroiditis associated with IgG4-related disease in Japan2015
Author(s)
Takeshima K, Inaba H, Ariyasu H, Furukawa Y, Doi A, Nishi M, Hirokawa M, Yoshida A, Imai R, Akamizu T.
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Journal Title
Endocrine Journal
Volume: 62
Issue: 8
Pages: 725-731
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Distribution of serum immunoglobulin G4 levels in Hashimoto’s thyroiditis and clinical features of Hashimoto’s thyroiditis with elevated serum immunoglobulin G4 levels2015
Author(s)
Takeshima K, Ariyasu H, Inaba H, Inagaki Y, Yamaoka H, Furukawa Y, Doi A, Furuta H, Nishi M, Akamizu T.
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Journal Title
Endocrine Journal
Volume: 62
Issue: 8
Pages: 711-717
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Elevated serum immunoglobulin G4 levels in patients with Graves' disease and their clinical implications.2014
Author(s)
Inaba H, Takeshima K, Furukawa Y, Nishi M, Yamaoka H, Miyamoto W, Ota T, Doi A, Kawashima H, Ariyasu H, Wakasaki H, Furuta H, Nakao T, Sasaki H, Akamizu T.
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Journal Title
Thyroid
Volume: 24
Issue: 4
Pages: 736-743
DOI
Related Report
Peer Reviewed / Open Access
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