| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
It has been reported that podoplanin, a ligand of the platelet activation receptor CLEC-2, is expressed on synovial cells in the joint of patients with rheumatoid arthritis. In the present study, we investigated a role of CLEC-2 in thrumatoid arthritis.
The extent of experimental arthritis is significantly decreased in CLEC-2-deficient bone marrow-chimeric mice. Podoplanin stimulation by recombinant CLEC-2 increased inflammatory cytokines and cell proliferation.
We proposed that platelets are leaked from hyper-permeabilized capillaries during inflammation and that the interaction between platelet CLEC-2 and podoplanin in synovial cells exacerbate arthritis by inflammatory cytokines and cell proliferation.
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