A role of the platelet activation receptor CLEC-2 in rheumatoid arthritis: a possible target protein for an anti-rheumatic drug
| Project/Area Number |
26461399
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Research Collaborator |
SASAKI Tomoyuki
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | CLEC-2 / 血小板 / 関節リウマチ / ポドプラニン / 滑膜細胞 |
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| Outline of Final Research Achievements |
It has been reported that podoplanin, a ligand of the platelet activation receptor CLEC-2, is expressed on synovial cells in the joint of patients with rheumatoid arthritis. In the present study, we investigated a role of CLEC-2 in thrumatoid arthritis.
The extent of experimental arthritis is significantly decreased in CLEC-2-deficient bone marrow-chimeric mice. Podoplanin stimulation by recombinant CLEC-2 increased inflammatory cytokines and cell proliferation.
We proposed that platelets are leaked from hyper-permeabilized capillaries during inflammation and that the interaction between platelet CLEC-2 and podoplanin in synovial cells exacerbate arthritis by inflammatory cytokines and cell proliferation.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] The platelet-activating receptor C-type lectin receptor-2 plays an essential role in liver regeneration after partial hepatectomy in mice.2017
Author(s)
Kono H, Fujii H, Suzuki-Inoue K, Inoue O, Furuya S, Hirayama K, Akazawa Y, Nakata Y, Sun C, Tsukiji N, Shirai T, Ozaki Y
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Journal Title
Journal of thrombosis and haemostasis
Volume: 印刷中
Issue: 5
Pages: 1-11
DOI
Related Report
Peer Reviewed
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[Journal Article] CLEC-2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice.2016
Author(s)
Shirai, Toshiaki Inoue, Osamu Tamura, Shogo Tsukiji, Nagaharu Sasaki, Tomoyuki Endo, Hiroshi Satoh, Kaneo Osada, Makoto Sato-Uchida, Hitomi Fujii, Hideki Ozaki, Yukio Suzuki-Inoue, Katsue
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Journal Title
Journal of thrombosis and haemostasis
Volume: 38
Issue: 3
Pages: 42-49
DOI
Related Report
Peer Reviewed
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[Journal Article] Platelets regulate the migration of keratinocytes via podoplanin/CLEC-2 signaling during cutaneous wound healing in mice.2016
Author(s)
Asai J, Hirakawa S, Sakabe J, Kishida T, Nakamura N, Takenaka H, Mazda O, Urano T, Suzuki-Inoue K, Tokura Y, Katoh N.
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Journal Title
Am J Pathol
Volume: 186
Issue: 1
Pages: 101-108
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Measurement of soluble C-type lectin-like receptor 2 in human plasma2015
Author(s)
Kazama F, Nakamura J, Osada M, Inoue O, Oosawa M, Tamura S, Tsukiji N, Aida K, Kawaguchi A, Takizawa S, Kaneshige A, Tanaka S, Suzuki-Inoue K, & Ozaki Y
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Journal Title
Platelets
Volume: 26
Issue: 8
Pages: 711-719
DOI
Related Report
Peer Reviewed
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[Presentation] 血栓止血を超えた血小板の役割2016
Author(s)
井上 克枝
Organizer
第34 回 日本臨床化学会甲信越支部総会
Place of Presentation
石和温泉ホテル甲斐路（笛吹市石和町）
Year and Date
2016-06-11
Related Report
Invited
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[Presentation] 血小板とリンパ管発生2014
Author(s)
井上克枝
Organizer
第76回 日本血液学会学術集会 教育講演
Place of Presentation
大阪国際会議場、大阪
Year and Date
2014-10-31 – 2014-11-02
Related Report
Invited
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