A novel cytoprotective agent with thrombomodulin mutant
Project/Area Number |
26461406
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Fukushima Medical University (2016) Kochi University (2014-2015) |
Principal Investigator |
|
Research Collaborator |
NISHIOKA Chie 高知大学, 医学部, 研究員
YANG Jing 高知大学, 医学部, 外国人特別研究員
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | thrombomodulin / transplantation / SOS / トロンボモジュリン |
Outline of Final Research Achievements |
We previously reported that the 4th and 5th epidermal growth factor like domain of thrombomodulin (TME45) possesses cytoprotective as well as pro-angiogenic activities. The current study has found that these activities were preserved in the TME5. Further studies employed immunoprecipitation followed by proteomic analysis to identify the cell surface protein which interacts with TME5. We found that TME5 binds to chemokine receptor GPR15, leading to activation of intracellular pro-survival signaling in vascular endothelial cells.
|
Report
(4 results)
Research Products
(17 results)
-
-
-
-
-
-
[Journal Article] The fifth epidermal growth factor-like region of thrombomodulin exerts cytoprotective function and prevents SOS in a murine model2017
Author(s)
Takayuki Ikezoe, Jing Yang, Chie Nishioka, Bin Pan, Kailin Xu, Mutsuo Furihata, Keigo Nakamura, Hiroya Yurimoto, Yasuyoshi Sakai, Goichi Honda, and Akihito Yokoyama
-
Journal Title
Bone Marrow Transplant.
Volume: 52
Issue: 1
Pages: 73-79
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation.2016
Author(s)
Nomura S, Maeda Y, Ishii K, Katayama Y, Yagi H, Fujishima N, Ota S, Moriyama M, Ikezoe T, Miyazaki Y, Hayashi K, Fujita S, Satake A, Ito T, Kyo T, Tanimoto M.
-
Journal Title
J Blood Med.
Volume: 7
Pages: 1-4
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-