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HSC regulation by TERT-binding proteins, chromatin remodeling factor BRG1/BRM

Research Project

Project/Area Number 26461411
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionChiba University

Principal Investigator

Nitta Eriko  千葉大学, 大学院医学研究院, 特任助教 (80401123)

Research Collaborator SUDA Toshio   (60118453)
IWAMA Atsushi   (70244126)
YAMASHITA Masayuki  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords造血幹細胞 / エピジェネティクス / クロマチンリモデリング / BRG1 / BRM / TERT / クロマチンリモデリング因子
Outline of Final Research Achievements

Among many players in the epigenetic regulation, the SWI/SNF ATP-dependent chromatin remodeling factor BRG1 has recently been demonstrated to be essential for leukemic stem cell (LSC) maintenance. Whereas BRG1 is implicated in the pathogenesis of Fanconi anemia and bone marrow failure, BRM, the homologue of BRG1, is expressed more specifically in HSCs compared with BRG1 and appeared to be involved in physiological regulation of HSCs. We have demonstrated an essential role of BRM in the maintenance of HSCs using genetically modified BRM-null mice. BRM-null HSCs showed profoundly impaired reconstitution capacity in competitive BMT assays and exhibited more activate cell cycling than wild type HSCs after bone marrow transplantation, suggesting that BRM plays a role in reversion of cycling HSCs into a quiescent state.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (3 results)

  • [Journal Article] Regulation of hematopoietic stem cell integrity through p53 and its related factors.2016

    • Author(s)
      Yamashita M, Nitta E, Suda T.
    • Journal Title

      Ann N Y Acad Sci.

      Volume: 印刷中 Issue: 1 Pages: 92-100

    • DOI

      10.1111/nyas.12986

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aspp1 preserves hematopoietic stem cell pool integrity and prevents malignant transformation.2015

    • Author(s)
      Yamashita M, Nitta E, Suda T.
    • Journal Title

      Cell Stem Cell.

      Volume: 17 Issue: 1 Pages: 23-34

    • DOI

      10.1016/j.stem.2015.05.013

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Maintenance of hematopoietic stem cell integrity and regulation of leukemogenesis by p53 and its coactivator Aspp12015

    • Author(s)
      Yamashita M, Nitta E, Suda T.
    • Journal Title

      Rinsho Ketsueki

      Volume: 56 Issue: 12 Pages: 2426-2433

    • DOI

      10.11406/rinketsu.56.2426

    • NAID

      130005116917

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] がん幹細胞化のメカニズム2015

    • Author(s)
      仁田英里子、岩間厚志
    • Journal Title

      日本臨床

      Volume: 73 Pages: 733-738

    • Related Report
      2014 Research-status Report
  • [Presentation] Aspp1 preserves hematopoietic stem cell pool integrity and prevents malignant transformation.2016

    • Author(s)
      仁田英里子
    • Organizer
      BMS血液学アカデミー
    • Place of Presentation
      ホテル日航福岡(福岡県福岡市)
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Chromatin remodeling factor BRM is essential for maintenance of HSC quiescence.2015

    • Author(s)
      Eriko Nitta
    • Organizer
      第77回日本血液学会総会
    • Place of Presentation
      ホテル日航金沢(石川県・金沢市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] Chromatin remodeling factor BRM is essential for maintenance of HSC quiescence.2015

    • Author(s)
      Eriko Nitta
    • Organizer
      The 44th Annual Meeting of International Society of Experimental Hematology
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] クロマチンリモデリング因子BRMは造血幹細胞の静止期を維持しROSストレスから防御する2014

    • Author(s)
      仁田英里子
    • Organizer
      第76回日本血液学会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Chromatin remodeling factor BRM protects HSCs from ROS stress via maintaining quiescence.2014

    • Author(s)
      Eriko Nitta
    • Organizer
      The 43rd Anual Meeting of International Society of Experimantal Hematology
    • Place of Presentation
      Montreal (Canada)
    • Year and Date
      2014-08-21 – 2014-08-23
    • Related Report
      2014 Research-status Report
  • [Remarks] 千葉大学大学院 医学研究院 細胞分子医学

    • URL

      http://www.m.chiba-u.ac.jp/class/molmed/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 文部科学省科学研究費補助金 新学術領域研究(研究領域提案型)ステムセルエイジングから解明する疾患原理

    • URL

      http://www.m.chiba-u.ac.jp/class/molmed/stemcellaging/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 文部科学省科学研究費補助金 新学術領域研究 ステムセルエイジングから解明する疾患原理

    • URL

      http://www.m.chiba-u.ac.jp/class/molmed/stemcellaging/

    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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