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Elucidation of pathogenic mechanism of adult T-cell leukemia induced by abnormal ROS regulation

Research Project

Project/Area Number 26461417
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionNiigata University

Principal Investigator

Takahashi Masahiko  新潟大学, 医歯学系, 准教授 (80377192)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsATL / HTLV-1 / USP10 / Tax / ストレス顆粒
Outline of Final Research Achievements

Adult T-cell leukemia (ATL) is an aggressive hematologic malignancy of poor prognosis caused by human T-cell leukemia virus type 1 (HTLV-1), and it is imperative to develop therapeutic drugs for chemotherapy against ATL. As arsenite or proteasome inhibitor bortezomib induce cell death in HTLV-1-infected T-cells, antitumor effect on ATL can be expected by using these drugs. In this study, we identified that ubiquitin-specific protease 10 (USP10) confers drug resistance phenotype to HTLV-1-infected T-cells. Based on this result, we are currently attempting to identify cellular defense mechanism against drug treatment that USP10 is involved.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results)

  • [Journal Article] Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.2016

    • Author(s)
      Motai Y, Takahashi M, Takachi T, Higuchi M, Hara T, Mizuguchi M, Aoyagi Y, Terai S, Tanaka Y, Fujii M.
    • Journal Title

      Virus Genes.

      Volume: 52 Issue: 1 Pages: 4-13

    • DOI

      10.1007/s11262-015-1277-7

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] USP10 Is an Essential Deubiquitinase for Hematopoiesis and Inhibits Apoptosis of Long-Term Hematopoietic Stem Cells.2016

    • Author(s)
      Higuchi M, Kawamura H, Matsuki H, Hara T, Takahashi M, Saito S, Saito K, Jiang S, Naito M, Kiyonari H, Fujii M.
    • Journal Title

      Stem Cell Reports

      Volume: 7 Issue: 6 Pages: 1116-1129

    • DOI

      10.1016/j.stemcr.2016.11.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells2015

    • Author(s)
      Takachi T, Takahashi M, Takahashi-Yoshita M, Higuchi M, Obata M, Mishima Y, Okuda S, Tanaka Y, Matsuoka M, Saitoh A, Green PL, Fujii M.
    • Journal Title

      Cance Science

      Volume: 106(4) Issue: 4 Pages: 461-465

    • DOI

      10.1111/cas.12618

    • NAID

      120006844098

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells.2015

    • Author(s)
      Saito S, Kawamura T, Higuchi M, Kobayashi T, Yoshita-Takahashi M, Yamazaki M, Abe M, Sakimura K, Kanda Y, Kawamura H, Jiang S, Naito M, Yoshizaki T, Takahashi M, Fujii M.
    • Journal Title

      Eur J Immunol.

      Volume: in press Issue: 5 Pages: 1512-1523

    • DOI

      10.1002/eji.201444977

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Downregulation of proapoptotic Bim augments IL-2-independent T-cell transformation by human T-cell leukemia virus type-1 Tax.2014

    • Author(s)
      Higuchi M, Takahashi M, Tanaka Y, Fujii M.
    • Journal Title

      Cancer Med.

      Volume: 3 Issue: 6 Pages: 1605-1614

    • DOI

      10.1002/cam4.329

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

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Published: 2014-04-04   Modified: 2018-03-22  

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