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NKEA project: Next-Generation Therapy for NK/T-cell lymphoma in East Asia

Research Project

Project/Area Number 26461418
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionMie University

Principal Investigator

Yamaguchi Motoko  三重大学, 医学部附属病院, 講師 (50359767)

Co-Investigator(Kenkyū-buntansha) 鈴木 律朗  三重大学, 医学系研究科, リサーチアソシエイト (20280810)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsNK/T細胞リンパ腫 / 新世代治療 / RT-2/3DeVIC療法 / 多施設共同研究 / 国際情報交換 / 東アジア / 韓国:香港:中国
Outline of Final Research Achievements

We conducted a retrospective study including patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKL) diagnosed between 2000 and 2013 in 31 institutes in Japan (NKEA Part A) and elucidated the current status of next-generation therapy in clinical practice in Japan. The median age at diagnosis of all 358 patients was 58 years. Of 257 patients with localized ENKL, 66% received RT-DeVIC as first-line therapy. Efficacy and toxicity of RT-DeVIC in those patients were comparable to those in the JCOG0211 trial. Elevated pretreatment serum soluble IL-2 receptor was associated with short survival in those patients. L-asparaginase-containing chemotherapy was selected in 30% of 101 patients with untreated advanced ENKL.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (23 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Book (2 results) Remarks (2 results)

  • [Int'l Joint Research] Samsung Medical Center(韓国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Samsung Medical Center(韓国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Treatments and outcomes of patients with extranodal natural killer/T-cell lymphoma diagnosed between 2000 and 2013: a cooperative study in Japan2017

    • Author(s)
      Yamaguchi M, Suzuki R, Oguchi M, Asano N, Amaki J, Akiba T, Maeda T, Itasaka S, Kubota N, Saito Y, Kobayashi Y, Itami J, Ueda K, Miyazaki K, Ii N, Tomita N, Sekiguchi N, Takizawa J, Saito B, Murayama T, Ando T, Wada H, Hyo R, Ejima Y, Hasegawa M, Katayama N
    • Journal Title

      J Clin Oncol

      Volume: 35 Issue: 1 Pages: 32-39

    • DOI

      10.1200/jco.2016.68.1619

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of new treatments for extranodal NK/T-cell lymphoma in Japan2015

    • Author(s)
      山口素子
    • Journal Title

      Rinsho Ketsueki

      Volume: 56 Issue: 6 Pages: 639-644

    • DOI

      10.11406/rinketsu.56.639

    • NAID

      130005093095

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic biomarkers in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy.2014

    • Author(s)
      Yamaguchi M, Takata K, Yoshino T, Ishizuka N, Oguchi M, Kobayashi Y, Isobe Y, Ishizawa K, Kubota N, Itoh K, Usui N, Miyazaki K, Wasada I, Nakamura S, Matsuno Y, Oshimi K, Kinoshita T, Tsukasaki K, Tobinai K.
    • Journal Title

      Cancer Sci

      Volume: 105 Issue: 11 Pages: 1435-1441

    • DOI

      10.1111/cas.12526

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 造血器腫瘍診療におけるガイドラインの利用と展望 T/NK細胞リンパ腫2014

    • Author(s)
      山口素子
    • Journal Title

      癌と化学療法

      Volume: 41 Pages: 576-579

    • Related Report
      2014 Research-status Report
  • [Journal Article] (R-)CHOP療法が標準療法ではない悪性リンパ腫2014

    • Author(s)
      山口素子
    • Journal Title

      腫瘍内科

      Volume: 14 Pages: 543-554

    • Related Report
      2014 Research-status Report
  • [Presentation] Early disease progression in patients (pts) with newly diagnosed localized nasal extranodal NK/T-cell lymphoma, nasal type (ENKL) treated with radiotherapy with dexamethasone, etoposide, ifosfamide, and carboplatin (RT-DeVIC)2017

    • Author(s)
      Yamaguchi M, et al.
    • Organizer
      2017 ASCO Annual Meeting
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2017-06-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「致死性」と呼ばれた疾患の治癒をめざして2016

    • Author(s)
      山口素子
    • Organizer
      第78回日本血液学会学術集会 女性医師・研究者シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 2000年以降に診断された節外性NK/T細胞リンパ腫の治療と予後:NKEA研究2016

    • Author(s)
      山口素子、ほか
    • Organizer
      第78回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] T/NK細胞リンパ腫の治療方針2016

    • Author(s)
      山口素子
    • Organizer
      第56回日本リンパ網内系学会総会 教育シンポジウム
    • Place of Presentation
      ホテル日航熊本(熊本県・熊本市)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Outcomes and prognostic factors of RT-DeVIC for newly diagnosed, localized ENKL: a cooperative study in Japan2016

    • Author(s)
      Yamaguchi M, et al.
    • Organizer
      2016 ASCO Annual Meeting
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2016-06-06
    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血液がん治療の進歩 最新情報を知る NK/T細胞リンパ腫に対するSMILE療法2015

    • Author(s)
      山口素子
    • Organizer
      日本癌治療学会学術集会 臓器別シンポジウム
    • Place of Presentation
      グランドプリンスホテル京都(京都府・京都市)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] NK/T-cell lymphoma: the role of asparaginase - Japanese experience2015

    • Author(s)
      Yamaguchi M
    • Organizer
      T-Cell Lymphoma Forum in Bologna
    • Place of Presentation
      Bologna, Italy
    • Year and Date
      2015-04-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Expression of LMO3 and SNAP25 in Diffuse Large B-Cell Lymphoma Cells and Its Relation to Clinical Features2014

    • Author(s)
      Kobayashi K, Yamaguchi M, Miyazaki K, Imai H, Yokoe K, Ono R, Nosaka T, Katayama N
    • Organizer
      56th ASH Annual Meeting & Exposition
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-12-07
    • Related Report
      2014 Research-status Report
  • [Presentation] Advances in the treatment of NK-cell malignancies Extranodal NK/T-cell lymphoma (ENKL)2014

    • Author(s)
      Yamaguchi M
    • Organizer
      第76回日本血液学会学術集会 (シンポジウム)
    • Place of Presentation
      大阪国際会議場, 大阪
    • Year and Date
      2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Progress in the diagnosis and treatment of malignant lymphoma2014

    • Author(s)
      Yamaguchi M
    • Organizer
      第73回日本癌学会学術総会 (腫瘍別シンポジウム)
    • Place of Presentation
      パシフィコ横浜, 横浜
    • Year and Date
      2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Management of localized and advanced NK/T-cell lymphoma based on Asian trials2014

    • Author(s)
      山口素子
    • Organizer
      第54回日本リンパ網内系学会総会 (シンポジウム)
    • Place of Presentation
      山形国際ホテル, 山形
    • Year and Date
      2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Treatment approaches for NK/T-cell lymphoma based on clinical trials2014

    • Author(s)
      Yamaguchi M
    • Organizer
      1st Taiwan-Japan Hematology Forum
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2014-04-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] EBM血液疾患の治療2015-2016 節外性NK/T細胞リンパ腫の治療方針2014

    • Author(s)
      山口素子
    • Total Pages
      555
    • Publisher
      中外医学社
    • Related Report
      2014 Research-status Report
  • [Book] レベルアップのためのリンパ腫セミナー 節外性NK/T細胞リンパ腫、鼻型 (ENKL)2014

    • Author(s)
      山口素子
    • Total Pages
      260
    • Publisher
      南江堂
    • Related Report
      2014 Research-status Report
  • [Remarks] NKEA project

    • URL

      https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000018002

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
  • [Remarks] NKEA project

    • URL

      https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000018002&type=summary&language=J

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2022-02-16  

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