NKEA project: Next-Generation Therapy for NK/T-cell lymphoma in East Asia

• Project/Area Number: 26461418
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Mie University
• Principal Investigator: Yamaguchi Motoko 三重大学, 医学部附属病院, 講師 (50359767)
• Co-Investigator(Kenkyū-buntansha): 鈴木 律朗 三重大学, 医学系研究科, リサーチアソシエイト (20280810)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: NK/T細胞リンパ腫 / 新世代治療 / RT-2/3DeVIC療法 / 多施設共同研究 / 国際情報交換 / 東アジア / 韓国：香港：中国

Outline of Final Research Achievements

We conducted a retrospective study including patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKL) diagnosed between 2000 and 2013 in 31 institutes in Japan (NKEA Part A) and elucidated the current status of next-generation therapy in clinical practice in Japan. The median age at diagnosis of all 358 patients was 58 years. Of 257 patients with localized ENKL, 66% received RT-DeVIC as first-line therapy. Efficacy and toxicity of RT-DeVIC in those patients were comparable to those in the JCOG0211 trial. Elevated pretreatment serum soluble IL-2 receptor was associated with short survival in those patients. L-asparaginase-containing chemotherapy was selected in 30% of 101 patients with untreated advanced ENKL.

Research Products

• [Int'l Joint Research] Samsung Medical Center(韓国)
• [Int'l Joint Research] Samsung Medical Center(韓国)
• [Journal Article] Treatments and outcomes of patients with extranodal natural killer/T-cell lymphoma diagnosed between 2000 and 2013: a cooperative study in Japan (2017)
  • Author(s): Yamaguchi M, Suzuki R, Oguchi M, Asano N, Amaki J, Akiba T, Maeda T, Itasaka S, Kubota N, Saito Y, Kobayashi Y, Itami J, Ueda K, Miyazaki K, Ii N, Tomita N, Sekiguchi N, Takizawa J, Saito B, Murayama T, Ando T, Wada H, Hyo R, Ejima Y, Hasegawa M, Katayama N
  • Journal Title: J Clin Oncol Volume: 35 Issue: 1 Pages: 32-39
  • DOI: 10.1200/jco.2016.68.1619
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of new treatments for extranodal NK/T-cell lymphoma in Japan (2015)
  • Author(s): 山口素子
  • Journal Title: Rinsho Ketsueki Volume: 56 Issue: 6 Pages: 639-644
  • DOI: 10.11406/rinketsu.56.639
  • NAID: 130005093095
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] Prognostic biomarkers in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy. (2014)
  • Author(s): Yamaguchi M, Takata K, Yoshino T, Ishizuka N, Oguchi M, Kobayashi Y, Isobe Y, Ishizawa K, Kubota N, Itoh K, Usui N, Miyazaki K, Wasada I, Nakamura S, Matsuno Y, Oshimi K, Kinoshita T, Tsukasaki K, Tobinai K.
  • Journal Title: Cancer Sci Volume: 105 Issue: 11 Pages: 1435-1441
  • DOI: 10.1111/cas.12526
  • Peer Reviewed
• [Journal Article] 造血器腫瘍診療におけるガイドラインの利用と展望 T/NK細胞リンパ腫 (2014)
  • Author(s): 山口素子
  • Journal Title: 癌と化学療法 Volume: 41 Pages: 576-579
• [Journal Article] (R-)CHOP療法が標準療法ではない悪性リンパ腫 (2014)
  • Author(s): 山口素子
  • Journal Title: 腫瘍内科 Volume: 14 Pages: 543-554
• [Presentation] Early disease progression in patients (pts) with newly diagnosed localized nasal extranodal NK/T-cell lymphoma, nasal type (ENKL) treated with radiotherapy with dexamethasone, etoposide, ifosfamide, and carboplatin (RT-DeVIC) (2017)
  • Author(s): Yamaguchi M, et al.
  • Organizer: 2017 ASCO Annual Meeting
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2017-06-05
  • Int'l Joint Research
• [Presentation] 「致死性」と呼ばれた疾患の治癒をめざして (2016)
  • Author(s): 山口素子
  • Organizer: 第78回日本血液学会学術集会 女性医師・研究者シンポジウム
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-15
  • Invited
• [Presentation] 2000年以降に診断された節外性NK/T細胞リンパ腫の治療と予後：NKEA研究 (2016)
  • Author(s): 山口素子、ほか
  • Organizer: 第78回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-10-13
• [Presentation] T/NK細胞リンパ腫の治療方針 (2016)
  • Author(s): 山口素子
  • Organizer: 第56回日本リンパ網内系学会総会 教育シンポジウム
  • Place of Presentation: ホテル日航熊本（熊本県・熊本市）
  • Year and Date: 2016-09-03
  • Invited
• [Presentation] Outcomes and prognostic factors of RT-DeVIC for newly diagnosed, localized ENKL: a cooperative study in Japan (2016)
  • Author(s): Yamaguchi M, et al.
  • Organizer: 2016 ASCO Annual Meeting
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2016-06-06
  • Int'l Joint Research
• [Presentation] 血液がん治療の進歩 最新情報を知る NK/T細胞リンパ腫に対するSMILE療法 (2015)
  • Author(s): 山口素子
  • Organizer: 日本癌治療学会学術集会 臓器別シンポジウム
  • Place of Presentation: グランドプリンスホテル京都（京都府・京都市）
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] NK/T-cell lymphoma: the role of asparaginase - Japanese experience (2015)
  • Author(s): Yamaguchi M
  • Organizer: T-Cell Lymphoma Forum in Bologna
  • Place of Presentation: Bologna, Italy
  • Year and Date: 2015-04-28
  • Int'l Joint Research / Invited
• [Presentation] Expression of LMO3 and SNAP25 in Diffuse Large B-Cell Lymphoma Cells and Its Relation to Clinical Features (2014)
  • Author(s): Kobayashi K, Yamaguchi M, Miyazaki K, Imai H, Yokoe K, Ono R, Nosaka T, Katayama N
  • Organizer: 56th ASH Annual Meeting & Exposition
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2014-12-07
• [Presentation] Advances in the treatment of NK-cell malignancies Extranodal NK/T-cell lymphoma (ENKL) (2014)
  • Author(s): Yamaguchi M
  • Organizer: 第76回日本血液学会学術集会 （シンポジウム）
  • Place of Presentation: 大阪国際会議場, 大阪
  • Year and Date: 2014-11-02
• [Presentation] Progress in the diagnosis and treatment of malignant lymphoma (2014)
  • Author(s): Yamaguchi M
  • Organizer: 第73回日本癌学会学術総会 （腫瘍別シンポジウム）
  • Place of Presentation: パシフィコ横浜, 横浜
  • Year and Date: 2014-09-27
• [Presentation] Management of localized and advanced NK/T-cell lymphoma based on Asian trials (2014)
  • Author(s): 山口素子
  • Organizer: 第54回日本リンパ網内系学会総会 （シンポジウム）
  • Place of Presentation: 山形国際ホテル, 山形
  • Year and Date: 2014-06-20
• [Presentation] Treatment approaches for NK/T-cell lymphoma based on clinical trials (2014)
  • Author(s): Yamaguchi M
  • Organizer: 1st Taiwan-Japan Hematology Forum
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2014-04-13
  • Invited
• [Book] EBM血液疾患の治療2015-2016 節外性NK/T細胞リンパ腫の治療方針 (2014)
  • Author(s): 山口素子
  • Total Pages: 555
  • Publisher: 中外医学社
• [Book] レベルアップのためのリンパ腫セミナー 節外性NK/T細胞リンパ腫、鼻型 (ENKL) (2014)
  • Author(s): 山口素子
  • Total Pages: 260
  • Publisher: 南江堂
• [Remarks] NKEA project
  • URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000018002
• [Remarks] NKEA project
  • URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000018002&type=summary&language=J