NKEA project: Next-Generation Therapy for NK/T-cell lymphoma in East Asia
Project/Area Number |
26461418
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Mie University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
鈴木 律朗 三重大学, 医学系研究科, リサーチアソシエイト (20280810)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | NK/T細胞リンパ腫 / 新世代治療 / RT-2/3DeVIC療法 / 多施設共同研究 / 国際情報交換 / 東アジア / 韓国:香港:中国 |
Outline of Final Research Achievements |
We conducted a retrospective study including patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKL) diagnosed between 2000 and 2013 in 31 institutes in Japan (NKEA Part A) and elucidated the current status of next-generation therapy in clinical practice in Japan. The median age at diagnosis of all 358 patients was 58 years. Of 257 patients with localized ENKL, 66% received RT-DeVIC as first-line therapy. Efficacy and toxicity of RT-DeVIC in those patients were comparable to those in the JCOG0211 trial. Elevated pretreatment serum soluble IL-2 receptor was associated with short survival in those patients. L-asparaginase-containing chemotherapy was selected in 30% of 101 patients with untreated advanced ENKL.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Treatments and outcomes of patients with extranodal natural killer/T-cell lymphoma diagnosed between 2000 and 2013: a cooperative study in Japan2017
Author(s)
Yamaguchi M, Suzuki R, Oguchi M, Asano N, Amaki J, Akiba T, Maeda T, Itasaka S, Kubota N, Saito Y, Kobayashi Y, Itami J, Ueda K, Miyazaki K, Ii N, Tomita N, Sekiguchi N, Takizawa J, Saito B, Murayama T, Ando T, Wada H, Hyo R, Ejima Y, Hasegawa M, Katayama N
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Journal Title
J Clin Oncol
Volume: 35
Issue: 1
Pages: 32-39
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Prognostic biomarkers in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy.2014
Author(s)
Yamaguchi M, Takata K, Yoshino T, Ishizuka N, Oguchi M, Kobayashi Y, Isobe Y, Ishizawa K, Kubota N, Itoh K, Usui N, Miyazaki K, Wasada I, Nakamura S, Matsuno Y, Oshimi K, Kinoshita T, Tsukasaki K, Tobinai K.
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Journal Title
Cancer Sci
Volume: 105
Issue: 11
Pages: 1435-1441
DOI
Related Report
Peer Reviewed
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