| Project/Area Number |
26461420
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
ICHII Michiko 大阪大学, 医学系研究科, 寄附講座助教 (30633010)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
金倉 譲 大阪大学, 医学系研究科, 教授 (20177489)
加藤 恒 大阪大学, 医学系研究科, 助教 (20705214)
横田 貴史 大阪大学, 医学系研究科, 助教 (60403200)
織谷 健司 大阪大学, 医学系研究科, 准教授 (70324762)
田所 誠司 大阪大学, 医学系研究科, 助教 (80403062)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YOKOSAKI Yasuyuki 広島大学, 保健管理センター, 准教授 (80210607)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 骨髄腫 / インテグリン / 多発性骨髄腫 |
|---|
| Outline of Final Research Achievements |
The purpose of this study is evaluating the role of integrin alpha 8 in the pathogenesis of multiple myeloma. It is reported that human plasma cells express integrin alpha 8. First, we analyzed the expression of integrin alpha 8 on myeloma cells. As a result, not all of myeloma cell lines express integrin alpha 8. In contrast, the expression of integrin alpha 8 was detected in myeloma cells derived from patient bone marrow and peripheral blood. The effect of integrin alpha 8 on proliferation and resistance against cytotoxic drugs seemed similar between integrin alpha 8 positive and negative myeloma cell lines. These results indicated that integrin alpha 8 might be useful for evaluating residual disease during treatment.
|
