| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The circadian rhythm, defined as daily oscillation in various biological processes, is controlled by an endogenous clock in most normal cells in the body. Circadian rhythm disruption by shift work is associated with greater risk for cancer development and poor prognosis, suggesting a putative tumor-suppressive role for circadian rhythm homeostasis. Recent findings demonstrate a previously unrecognized role for the core circadian clock genes in acute myeloid leukemia. In hematopoietic cancers, the regulatory role of circadian clock genes has not yet been entirely clarified. Using cell lines, primary leukemic cells, and a genetically engineered mouse model of leukemia, we have characterized the effects of circadian rhythm disruption on leukemogenesis. The drugs that alter the circadian rhythm may sensitize leukemia cells to traditional anti-cancer therapies and facilitate targeting of leukemic stem cells to eliminate disease more effectively.
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