| Project/Area Number |
26461426
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
吉浦 孝一郎 長崎大学, 原爆後障害医療研究所, 教授 (00304931)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 骨髄異形成症候群 / 原爆被ばく / 放射線 / 染色体異常 / ゲノム異常 / 原爆被爆者 / 造血器腫瘍 / ゲノム科学 / 遺伝子変異 / 放射線生物学 |
|---|
| Outline of Final Research Achievements |
We studied clinical features and genome alterations of MDS among atomic bomb survivors. We found that the frequency of abnormal karyotype was significantly higher in MDS among survivors exposed at closer distance from hypocenter, especially karyotypes related to poor prognosis, such as complex karyotypes. However, there was no significant difference in overall survival, cumulative incidence of leukemia, or leukemia-free survival by the distance from hypocenter. These findings suggested that the impact of cytogenetic abnormality could be different between de novo MDS and MDS among survivors. We analyzed genome alteration in a rare case of MDS that transformed into acute lymphoblastic leukemia, in which new genome alterations were obtained at transformation.
|
