Clinical features and genetic alterations of MDS among atomic bomb survivors.
Project/Area Number |
26461426
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Nagasaki University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
吉浦 孝一郎 長崎大学, 原爆後障害医療研究所, 教授 (00304931)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 骨髄異形成症候群 / 原爆被ばく / 放射線 / 染色体異常 / ゲノム異常 / 原爆被爆者 / 造血器腫瘍 / ゲノム科学 / 遺伝子変異 / 放射線生物学 |
Outline of Final Research Achievements |
We studied clinical features and genome alterations of MDS among atomic bomb survivors. We found that the frequency of abnormal karyotype was significantly higher in MDS among survivors exposed at closer distance from hypocenter, especially karyotypes related to poor prognosis, such as complex karyotypes. However, there was no significant difference in overall survival, cumulative incidence of leukemia, or leukemia-free survival by the distance from hypocenter. These findings suggested that the impact of cytogenetic abnormality could be different between de novo MDS and MDS among survivors. We analyzed genome alteration in a rare case of MDS that transformed into acute lymphoblastic leukemia, in which new genome alterations were obtained at transformation.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Clinical features and prognosis of patients with myelodysplastic syndromes who were exposed to atomic bomb radiation in Nagasaki.2016
Author(s)
Matsuo M, Iwanaga M, Kondo H, Soda M, Jo T, Horio K, Takasaki Y, Kawaguchi Y, Tsushima H, Imaizumi Y, Imanishi D, Taguchi J, Sawayama Y, Hata T, Miyazaki Y
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Journal Title
Cancer Science
Volume: 107
Pages: 1484-1491
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Proposal of criteria for dyserythropoiesis in the diagnosis of myelodysplastic syndromes.2016
Author(s)
Kawai N, Matsuda A, Jinnai I, Ichimura T, Kayano H, Okamura D, Ishikawa M, Maeda T, Hata T, Miyazaki Y, Asou N, Bessho M, Tomonaga M.
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Journal Title
Int J Hematol
Volume: 103
Issue: 2
Pages: 227-233
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] The Level of Bone Marrow WT1 Message is a Useful Marker to Differentiate Myelodysplastic Syndromes with Low Blast Percentage from Cytopenia due to Other Reasons2015
Author(s)
Baba M, Hata T, Tsushima H, Mori S, Sasaki D, Turuta K, Hasegawa H, Ando K, Sawayama Y, Imanishi D, Taguchi J, Yanagihara K, Tomonaga M, Kamihira S, Miyazaki Y
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Journal Title
Internal Medicine
Volume: 54
Issue: 5
Pages: 445-451
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM).2015
Author(s)
Della Porta MG, Tuechler H, Malcovati L, , Miyazaki Y, Sekeres MA, Sperr WR, Stauder R, Tauro S, van de Loosdrecht AA, Germing U, Haase D, Greenberg PL, Cazzola M, et al.
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Journal Title
Leukemia
Volume: 29
Issue: 7
Pages: 1502-1513
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methltransferase DNMT3B.2014
Author(s)
Itonaga H, Imanishi D, Wong YF, Sato S, Ando K, Sawayama Y, Sasaki D, Tsuruda K, Hasegawa H, Imaizumi Y, Taguchi J, Tsushima H, Yoshida S, Fukushima T, Hata T, Moriuchi Y, Yanagihara K, Miyazaki Y.
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Journal Title
Leukemia
Volume: in press
Issue: 7
Pages: 1459-1466
DOI
Related Report
Peer Reviewed
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[Presentation] Clonal evolution underlying the progression from MDS to Ph-positive ALL.2016
Author(s)
Masataka Taguchi, Tomoko Kohno, Hiroyuki Mishima, Hiroaki Taniguchi, Hidehiro Itonaga, Takeharu Kato, Shinya Sato, Akira Kinoshita, Tomoko Hata, Yukiyoshi Moriuchi, Koh-Ichiro Yoshiura, Yasushi Miyazaki
Organizer
日本血液学会学術総会
Place of Presentation
パシフィコ横浜(神奈川県・横浜市)
Year and Date
2016-10-13
Related Report
Int'l Joint Research
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[Presentation] Genetic Predispositions to Myeloid Neoplasms Caused By Germline DDX41 Mutations.2015
Author(s)
Takeda J, Yoshida J, Makishima H, Miyazaki Y, Naoe T, Miyano S, Usuki K, Miyawaki S, Kamatani Y, Momozawa K, Kubo M, Polprasert C, Maciejewski JP, Ogawa S, et al.
Organizer
57th Annual Meeting and Exposition, American Society of Hematology
Place of Presentation
Orlando, Florida, USA
Year and Date
2015-12-05
Related Report
Int'l Joint Research
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[Presentation] Acute Monoblastic Leukemia and Myeloproliferative Neoplasm Observed in an Elderly Man Had the Same Clonal Origin.2015
Author(s)
Sato S, Miyazaki Y, Itonaga H, Taguchi M, Sawayama Y, Imanishi D, Hata T, Moriuchi Y, Mishima H, Yoshiura K.
Organizer
57th Annual Meeting and Exposition, American Society of Hematology
Place of Presentation
Orlando, Florida, USA
Year and Date
2015-12-05
Related Report
Int'l Joint Research