| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The project was intended to improve the efficacy of therapeutic neovascularization, which mends limb ischemia due to atherosclerosis and similar illness that obstruct blood perfusion. We found a molecule that improve neovascularization, and introduced its gene into iPS cells. They were differentiated into platelets, and injected into ischemic limb. During this differentiation process, cell nucleus containing introduced gene are eliminated, making the therapy safer than the ordinary gene therapies. In this funding program we could not afford to obtain enough amount of platelet. But our preliminary investigation using fewer platelets showed that the therapy recovers ischemia to some extent. We are willing to further promote our project, which seems promising to be applied into clinical application.
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