| Project/Area Number |
26461443
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Mie University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
岩本 彰太郎 三重大学, 医学系研究科, 助教 (20456734)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TOYODA Hidemi 三重大学, 医学部附属病院, 講師 (60525327)
|
|---|
| Research Collaborator |
HANAKI Ryo 三重大学, 医学部附属病院, 医員 (40780408)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 移植片対宿主病 / マクロファージ / 単球 / 造血細胞移植 / GVHD / ELISPOT法 / 慢性GVHD / 炎症性単球 / 抗炎症性単球 / 免疫組織染色法 / フローサイトメーター / 抗炎症性マクロファージ |
|---|
| Outline of Final Research Achievements |
Treatment of chronic GVHD, which influences prognosis after hematopoietic cell transplantation, has not yet been established. We have previously demonstrated that anti-inflammatory monocytes produce IL-10 in chronic GVHD and are involved in the repair of damaged target organs. There are inflammatory M1 type and anti - inflammatory type M2 type in macrophages. Using this M2 macrophage, a novel treatment for GVHD has developed. Two types of macrophages M1 and M2 were induced by culturing them with cytokines of GM-CSF and M-CSF from mouse bone marrow cells. In murine GVHD model, M2 macrophages reduced lethal GVHD and improved survival rate. Future clinical application has been expected.
|
