The role of STAP-2 in hematological diseases
Project/Area Number |
26461444
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Osaka University |
Principal Investigator |
MAEDA Tetsuo 大阪大学, 医学系研究科, 助教 (00403064)
|
Co-Investigator(Kenkyū-buntansha) |
金倉 譲 大阪大学, 医学系研究科, 教授 (20177489)
齊藤 則充 大阪大学, 医学系研究科, 特任助教(常勤) (30597399)
一井 倫子 大阪大学, 医学系研究科, 寄附講座助教 (30633010)
織谷 健司 大阪大学, 医学系研究科, 准教授 (70324762)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | STAP蛋白 / アダプター蛋白 / STAP / EBウイルス / リンパ腫 / 遺伝子多型 / シグナル / 免疫 / 炎症 / 骨髄微小環境 / リンパ球 |
Outline of Final Research Achievements |
Previously, we have reported that Signal transducing adaptor protein (STAP) binds latent membrane protein-1 in Epstein-Barr virus (EBV), and Bcr-Abl fusion protein, which causes chronic myeloid leukemia (CML). In this study we studied the role of STAP family in various hematological diseases. We found that STAP-1 is down-regulated in EBV-induced post transplantation lymphoproliferative disorder compared with EBV-negative de novo DLBCL. Regarding the effect on CML, STAP-1 deficiency improved the survival of CML model mouse. Further study would clarify the precise molecular mechanisms.
|
Report
(4 results)
Research Products
(12 results)
-
-
[Journal Article] ESAM is a novel human hematopoietic stem cell marker associated with a subset of human leukemias.2016
Author(s)
Ishibashi T, Yokota T, Tanaka H, Ichii M, Sudo T, Satoh Y, Doi Y, Ueda T, Tanimura A, Hamanaka Y, Ezoe S, Shibayama H, Oritani K, Kanakura Y.
-
Journal Title
Experimental Hematology
Volume: 44
Issue: 4
Pages: 269-281
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] A new variant of acute promyelocytic leukemia with IRF2BP2-RARA fusion.2016
Author(s)
Shimomura Y, Mitsui H, Yamashita Y, Kamae T, Kanai A, Matsui H, Ishibashi T, Tanimura A, Shibayama H, Oritani K, Kuyama J, Kanakura Y.
-
Journal Title
Cancer Sci.
Volume: 107(8)
Issue: 8
Pages: 1165-1168
DOI
Related Report
Peer Reviewed
-
[Journal Article] A new STAT3-binding partner, ARL3, enhances the phosphorylation and nuclear accumulation of STAT3.2016
Author(s)
Togi S, Muromoto R, Hirashima K, Kitai Y, Okayama T, Ikeda O, Matsumoto N, Kon S, Sekine Y, Oritani K, Matsuda T.
-
Journal Title
J Biol Chem.
Volume: 印刷中
Issue: 21
Pages: 11161-11171
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] [Diffuse large B-cell lymphoma occurring in a Waldenström macroglobulinemia patient with central nervous system infiltration2015
Author(s)
Hayashi Y, Sata H, Akuta K, Toda J, Kusakabe S, Ueda T, Ueda Y, Fujita J, Tadokoro S, Maeda T, Nishimura J, Shibayama H, Oritani K, Kanakura Y
-
Journal Title
Rinsho Ketsueki
Volume: 56
Pages: 2351-2356
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis.2014
Author(s)
Fujita N, Oritani K, Ichii M, Yokota T, Saitoh N, Okuzaki D, Sekine Y, Kon S, Muromoto R, Saitoh K, Yoshimura A, Matsuda T, Kanakura Y.
-
Journal Title
Eur J Immunol.
Volume: 44
Issue: 6
Pages: 1791-1801
DOI
Related Report
Peer Reviewed / Open Access
-
[Presentation] Safety and Efficacy of a Switch to Nilotinib in Patients with CML-CP Showing MMR to Imatinib: Results of a Multicenter Phase II Trial (NILSw Trial)2016
Author(s)
Shibayama H, Kawaguchi T, Kuroda J, Nakamae H, Matsumura I, Miyamoto T, Ishikawa J, Kamimura T, Fukushima K, Imamura Y, Eto T, Sunami K, Shimokawa M, Akashi K, Kanakura Y
Organizer
The American Society of Hematology 58th Annual Meeting
Place of Presentation
SanDiego convention center, SanDiego, CA, USA
Year and Date
2016-12-03
Related Report
-
[Presentation] SATB1 Expression Helps in Identification of the Lymphoid-Lineage-Biased Trajectory of Func-tionally Fluctuating Hematopoietic Stem Cells2016
Author(s)
Doi Y, Yokota T, Satoh Y, Ueda T, Shingai Y, Ichii M, Tanimura A, Ezoe S, Shibayama H, Oritani K, Kohwi-Shigematsu T, Kanakura Y
Organizer
The American Society of Hematology 58th Annual Meeting
Place of Presentation
SanDiego convention center, SanDiego, CA, USA
Year and Date
2016-12-03
Related Report
-
[Presentation] Anamorsin is essential for B-cell terminal differentiation.2016
Author(s)
Hamanaka Y, Shibayama H, Tanimura A, Yokota T, Ezoe S, Ichii M, Ishibashi T, Doi Y, Nagate Y, Oritani K, Kanakura Y
Organizer
21st Congress of the European Hematology Association
Place of Presentation
Bella Center, Copenhagen, Denmark
Year and Date
2016-06-09
Related Report
-
[Presentation] The role of Signal-Transducing Adaptor Protein-2 in early T lymphopoiesis in thymus2014
Author(s)
Ichii M, Fujita N, Maeda T, Okuzaki D, Sekine Y, Kon S, Muromoro R, Oritani K, Matsuda T, Kanakura Y
Organizer
The American Society of Hematology 56th Annual Meeting
Place of Presentation
San Francisco, CA, USA
Year and Date
2014-12-09
Related Report
-