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Identification of cancer-related antigen based on next-generation sequencing data

Research Project

Project/Area Number 26461448
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionOkayama University

Principal Investigator

Kondo Eisei  岡山大学, 医歯薬学総合研究科, 講師 (30379747)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords腫瘍免疫 / CTL / CD40-B / 白血病 / 腫瘍抗原 / テーラーメイド抗原
Outline of Final Research Achievements

Cancer-related missense somatic mutations (so-called neoantigens) can be recognized by cytotoxic T-cell as non-self tumor antigens. We have been reported that CD40-activated B cells are efficient antigen presenting cells and can be generated from small amount of peripheral blood. We aimed to identify acute myeloid leukemia associated neo-antigens from patients treated with allogeneic stem cell transplantation. We have assessed CD8+ T cell response against neoantigen candicates from two patints with written informed consent, but failed to detect it.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Immune checkpoint inhibitors and allogeneic hematopoietic stem cell transplantation2017

    • Author(s)
      近藤 英生、前田 嘉信
    • Journal Title

      Rinsho Ketsueki

      Volume: 58 Issue: 5 Pages: 506-513

    • DOI

      10.11406/rinketsu.58.506

    • NAID

      130005690175

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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