Identification of cancer-related antigen based on next-generation sequencing data
| Project/Area Number |
26461448
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Okayama University |
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Principal Investigator |
Kondo Eisei 岡山大学, 医歯薬学総合研究科, 講師 (30379747)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 腫瘍免疫 / CTL / CD40-B / 白血病 / 腫瘍抗原 / テーラーメイド抗原 |
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| Outline of Final Research Achievements |
Cancer-related missense somatic mutations (so-called neoantigens) can be recognized by cytotoxic T-cell as non-self tumor antigens. We have been reported that CD40-activated B cells are efficient antigen presenting cells and can be generated from small amount of peripheral blood. We aimed to identify acute myeloid leukemia associated neo-antigens from patients treated with allogeneic stem cell transplantation. We have assessed CD8+ T cell response against neoantigen candicates from two patints with written informed consent, but failed to detect it.
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Report
(5 results)
Research Products
(1 results)
