| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We demonstrated the structure of Japanese common HLA haplotypes using multi-SNP data in HLA region of 1500 patient-donor unrelated bone marrow transplantation (UR-BMT) pairs.
We also identified high-risk HLA alleles and haplotypes for severe acute graft-versus-host disease (aGVHD) using database of 6967 UR-BMT pairs from the Japan Marrow Donor Program. The patient and/or donor HLA-B*51:01 and patient HLA-C*14:02 were significantly associated with an increased risk of severe aGVHD. Furthermore, patient mismatched HLA-C*14:02 showed the highest risk of severe aGVHD and overall mortality among all patient mismatched HLA-C alleles. KIR2DL-ligand mismatch has been considered as high-risk HLA-C mismatch in Japanese UR-BMT, however our data demonstrated that the effect of KIR2DL-ligand mismatch was attributable to patient HLA-C*14:02 and donor HLA-C*15:02 mismatch combination. Patient mismatched HLA-C*14:02 should be considered a non-permissive HLA-C mismatch in donor selection for UR-BMT.
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