| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It is known that adipose tissue decreases along with fibrosis in systemic sclerosis, and that cytokine (adipokine) produced from adipose tissue is involved in the regulation of fibrosis. Apelin is one of adipokines and binds to the receptor, APJ, and regulates angiogenesis, cardiac function, adipocyte functions. Since apelin and fibrosis have not become clear, we aimed to elucidate the role of apelin in fibrosis. As a result, we clarified that apelin regulates fibrosis suppressively, and its mechanism is being elucidated. Based on the results of this study, clinical application to skin sclerosis in systemic sclerosis can be expected.
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