• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of Sox molecules in the development of autoimmune diseases

Research Project

Project/Area Number 26461461
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionChiba University

Principal Investigator

Suto Akira  千葉大学, 大学院医学研究院, 特任准教授 (50447306)

Co-Investigator(Kenkyū-buntansha) 鈴木 浩太郎  千葉大学, 医学部附属病院, 講師 (90554634)
Co-Investigator(Renkei-kenkyūsha) NAKAJIMA Hiroshi  千葉大学, 大学院医学研究院, 教授 (00322024)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsSox12 / 自己免疫性腸炎 / Sox5 / 腸炎 / SoxC / Treg / 自己免疫疾患
Outline of Final Research Achievements

We have previously shown that Sox5 and c-Maf cooperatively induce Th17 cell differentiation via the induction of RORγt as downstream targets of Stat3. However, the role of other Sox family molecules in the development of autoimmune diseases was still largely unknown. Here, we show that the expression of Sox12, a member of SoxC family, is significantly induced in Treg cells under inflammatory conditions. Although Sox12 is not required for the development of nTreg cells, Sox12 is involved in the development of pTreg cells under inflammatory conditions in adoptive transfer colitis models. Moreover, we found that enforced expression of Sox12 is sufficient to promote Foxp3 expression in CD4+ T cells even in the absence of TGF-β or IL-2 and that Sox12 binds to Foxp3 promoter and drives its transcription.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 2014 Other

All Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Acknowledgement Compliant: 8 results,  Open Access: 3 results) Presentation (1 results) Remarks (2 results)

  • [Journal Article] IκBNS induces Muc5ac expression in epithelial cells and causes airway hyperresponsiveness in murine asthma models2017

    • Author(s)
      Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori T, Suto A, Suzuki K, Hirose K, Takeda K, Nakajima H
    • Journal Title

      Allergy

      Volume: 印刷中 Issue: 7 Pages: 13079-13079

    • DOI

      10.1111/all.13079

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] T-bet inhibits innate lymphoid cell-mediated eosinophilic airway inflammation by suppressing IL-9 production2017

    • Author(s)
      Matsuki A, Takatori T, Makita S, Yokota M, Tamachi T, Suto A, Suzuki K, Hirose K, Nakajima H
    • Journal Title

      J. Allergy Clin. Immunol

      Volume: 印刷中 Issue: 4 Pages: 31023-31025

    • DOI

      10.1016/j.jaci.2016.08.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] IkBNS enhances follicular helper T-cell differentiation and function downstream of ASCL2.2016

    • Author(s)
      Hosokawa J, Suzuki K, Meguro K, Tanaka S, Maezawa Y, Suto A, Fujimura L, Sakamoto A, Clevers H, Ohara O, Nakajima H.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: S0091-6749 Issue: 1 Pages: 32476-32479

    • DOI

      10.1016/j.jaci.2016.10.047

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SOCS3 expressed in M2 macrophages attenuates contact hypersensitivity by suppressing MMP12 production2016

    • Author(s)
      Meguro K, Nakagomi D, Suzuki K, Hosokawa J, Fukuta T, Yokota M, Maezawa Y, Suto A, Nakajima H
    • Journal Title

      J Invest Dermatol

      Volume: in press Issue: 3 Pages: 649-57

    • DOI

      10.1016/j.jid.2015.12.010

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sox5 and Th17 cell differentiation.2015

    • Author(s)
      Suto A, Tanaka S, Nakajima H.
    • Journal Title

      Oncotarget.

      Volume: 6 Pages: 19952-3

    • Related Report
      2015 Research-status Report
  • [Journal Article] Roles of B Cell Leukemia/Lymphoma 3 in the development of T follicular helper cells and the pathogenesis of rheumatoid arthritis.2015

    • Author(s)
      Meguro, K., Suzuki, K., Hosokawa, J., Sanayama, Y., Tanaka, S., Furuta, S., Ikeda, K., Takatori, H, Suto, A., Sakamoto, A., Ohara, O., Nakajima, H.
    • Journal Title

      Arthritis & Rheumatology

      Volume: 67 Issue: 10 Pages: 2651-60

    • DOI

      10.1002/art.39266

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Helios enhances regulatory T cell function in cooperation with Foxp32015

    • Author(s)
      Takatori H, Kawashima H, Matsuki A, Meguro K, Tanaka S, Iwamoto T, Sanayama Y, Nishikawa N, Tamachi T, Ikeda K, Suto A, Suzuki K, Kagami S, Hirose K, Kubo M, Hori S, Nakajima H
    • Journal Title

      Arthritis Rheumatol

      Volume: 67 Issue: 6 Pages: 1491-502

    • DOI

      10.1002/art.39091

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MMP12 is produced by M2 monocytes-macrophages and plays important roles in the development of contact hypersensitivity2015

    • Author(s)
      Nakagomi D, Suzuki K, Meguro K, Hosokawa J, Tamachi T, Takatori H, Suto A, Matsue H, Ohara O, Nakayama T, Shimada S, Nakajima H
    • Journal Title

      J Allergy Clin Immunol

      Volume: 135 Issue: 5 Pages: 1397-400

    • DOI

      10.1016/j.jaci.2014.10.055

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Helios enhances regulatory T cell function in cooperation with Foxp3.2015

    • Author(s)
      Takatori H, Kawashima H, Matsuki A, Meguro K, Tanaka S, Iwamoto T, Sanayama Y, Nishikawa N, Tamachi T, Ikeda K, Suto A, Suzuki K, Kagami SI, Hirose K, Kubo M, Hori S, Nakajima H.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 未定

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sox5 and c-Maf cooperatively induce Th17 cell differentiation via ROR gamma t induction as downstream targets of Stat32014

    • Author(s)
      Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H
    • Journal Title

      J Exp Med

      Volume: 211 Issue: 9 Pages: 1857-1874

    • DOI

      10.1084/jem.20130791

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] IL-21-producing c-Maf-expressing CD4+ T cells induce effector CD8+ T cells and enhance autoimmune inflammation in scurfy mice2014

    • Author(s)
      Iwamoto T, Suto A, Tanaka S, Takatori H, Suzuki K, Iwamoto I, Nakajima H
    • Journal Title

      Arthritis Rheumatol

      Volume: (巻不明) Issue: 8 Pages: 2079-2090

    • DOI

      10.1002/art.38658

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Matrix metalloproteinase 12 is produced by M2 macrophages and plays important roles in the development of contact hypersensitivity.2014

    • Author(s)
      Nakagomi D, Suzuki K, Meguro K, Hosokawa J, Tamachi T, Takatori H, Suto A, Matsue H, Ohara O, Nakayama T, Shimada S, Nakajima H.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 未定

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] AT-rich interactive domain-containing protein 5a functions as a negative regulator of RORγt-induced Th17 cell differentiation.2014

    • Author(s)
      Saito Y, Kagami SI, Sanayama Y, Ikeda K, Suto A, Kashiwakuma D, Furuta S, Iwamoto I, Nonaka K, Ohara O, Nakajima H.
    • Journal Title

      Arthritis and Rheumatology

      Volume: 印刷中 Issue: 5 Pages: 1185-94

    • DOI

      10.1002/art.38324

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Role of Sox5 in the development of Th17 cells2014

    • Author(s)
      Suto A
    • Organizer
      The 2nd Symposium of International Immunological Memory and Vaccine Forum (IIMVF)
    • Place of Presentation
      La Jolla Institute for Allergy & Immunology (La Jolla, California, USA)
    • Year and Date
      2014-08-25 – 2014-08-26
    • Related Report
      2014 Research-status Report
  • [Remarks] 千葉大学大学院医学研究院 アレルギー・臨床免疫学

    • URL

      http://www.m.chiba-u.jp/class/allergy/research/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院 アレルギー・臨床免疫学 研究業績

    • URL

      http://www.m.chiba-u.jp/class/allergy/research/index.html

    • Related Report
      2015 Research-status Report 2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2021-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi