| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
CD180 (RP105) molecule is expressed on B cells. RP105 is associated with B cell function, survival and death. RP105-lacking B cells produce autoantibodies, including anti-ds-DNA antibodies in SLE. Large population of plasmablasts lacking RP105 are found in patients with systemic autoimmune diseases and take part in pathophysiology. We have studied clinical significance of RP105-negative B cells including plasmablasts in various immune-based diseases. We also analyzed the 5 sub-populations of plasmablasts in the various diseases. RP105-negative plasmablasts play crucial roles in systemic autoimmune and immune-based inflammatory disorders. Also, distribution of sub-population and difference of expressed antigens in RP105-lacking plasmablasts may be associated with pathophysiology in individual disorders.
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