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Immunologic function of podocytes in lupus nephritis

Research Project

Project/Area Number 26461467
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionNagasaki University

Principal Investigator

ICHINOSE Kunihiro  長崎大学, 医歯薬学総合研究科(医学系), 講師 (60437895)

Co-Investigator(Kenkyū-buntansha) 中村 英樹  長崎大学, 病院(医学系), 講師 (10437832)
岩本 直樹  長崎大学, 医歯薬学総合研究科(医学系), 助教 (80437897)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsループス腎炎 / 全身性エリテマトーデス / ポドサイト / CaMKIV / CD86 / 自己免疫性疾患
Outline of Final Research Achievements

We found that exposure of podocytes to IgG resulted in entry of IgG into the cytoplasm. DNA microarray studies of podocytes exposed to LN IgG revealed that genes that are related to the activation of immune cells or podocyte damage were upregulated.
LN IgG enters podocytes and upregulates CaMKIV followed by increased expression of genes known to be linked to podocyte damage and T cell activation. Targeted inhibition of CaMKIV in podocytes may prove of clinical use in patients with LN.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (26 results)

All 2017 2016 2015 2014 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 2 results,  Acknowledgement Compliant: 4 results) Presentation (14 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] 【全身性エリテマトーデス:病態解明の進歩】 神経精神SLE2017

    • Author(s)
      一瀬邦弘
    • Journal Title

      炎症と免疫

      Volume: 25 Pages: 133-138

    • Related Report
      2016 Annual Research Report
  • [Journal Article] SLEの中枢神経病変2017

    • Author(s)
      一瀬邦弘
    • Journal Title

      リウマチ科

      Volume: 57 Pages: 1-11

    • Related Report
      2016 Annual Research Report
  • [Journal Article] IgG4-Related Disease With an Aortoduodenal Fistula After Abdominal Aortic Aneurysm Repair.2016

    • Author(s)
      Ichinose K, Araki S, Takatani A, Tanaka T, Kawakami A.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 68 Issue: 9 Pages: 2256-2256

    • DOI

      10.1002/art.39777

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.2016

    • Author(s)
      Ichinose K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Iwamoto N, Tamai M, Arima K, Nakamura H, Obata Y, Yamamoto K, Origuchi T, Nishino T, Kawakami A, Tsokos GC.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 68 Issue: 4 Pages: 944-952

    • DOI

      10.1002/art.39499

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Predictors of clinical outcomes in patients with neuropsychiatric systemic lupus erythematosus.2016

    • Author(s)
      Ichinose K, Arima K, Umeda M, Fukui S, Nishino A, Nakashima Y, Suzuki T, Horai Y, Koga T, Kawashiri SY, Iwamoto N, Fujikawa K, Aramaki T, Tamai M, Nakamura H, Sato S, Origuchi T, Kawakami A.
    • Journal Title

      Cytokine.

      Volume: 79 Pages: 31-37

    • DOI

      10.1016/j.cyto.2015.12.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Soluble α-klotho is a potential biomarker associated with neuropsychiatric systemic lupus erythematosus.2016

    • Author(s)
      Ushigusa T, Ichinose K, Sato S, Michitsuji T, Shimizu T, Umeda M, Fukui S, Nishino A, Nakashima Y, Koga T, Kawashiri SY, Iwamoto N, Hirai Y, Tamai M, Nakamura H, Origuchi T, Kawakami A.
    • Journal Title

      Clin Immunol.

      Volume: 165 Pages: 29-34

    • DOI

      10.1016/j.clim.2016.03.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ループス腎炎の疾患標的分子と機能解析2016

    • Author(s)
      一瀬邦弘
    • Journal Title

      アレルギーの臨床

      Volume: 36 Pages: 446-452

    • Related Report
      2015 Research-status Report
  • [Journal Article] Proteomic profiling of antigens in circulating immune complexes associated with each of seven autoimmune diseases.2015

    • Author(s)
      Ohyama K, Baba M, Tamai M, Aibara N, Ichinose K, Kishikawa N, Kawakami A, Kuroda N.
    • Journal Title

      Clin Biochem.

      Volume: 48 Issue: 3 Pages: 181-185

    • DOI

      10.1016/j.clinbiochem.2014.11.008

    • NAID

      120006986232

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases.2014

    • Author(s)
      chinose K, Arima K, Ushigusa T, Nishino A, Nakashima Y, Suzuki T, Horai Y, Nakajima H, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Motomura M, Kawakami A.
    • Journal Title

      Clin Immunol.

      Volume: 157 Issue: 2 Pages: 114-120

    • DOI

      10.1016/j.clim.2015.01.010

    • NAID

      120006987160

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Combination of MRI-detcted bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability early rheumatoid arthritis.2014

    • Author(s)
      Tamai M, Kita J, Nakashima Y, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Yama-saki S, Nakamura H, Origuchi T, Uetani M,Fukushima A, Aoyagi K, Kawakami A.
    • Journal Title

      Annals of Rheumatic Diseases

      Volume: 73 Issue: 12 Pages: 2219-20

    • DOI

      10.1136/annrheumdis-2013-205074

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Evaluation of Soluble α-Klotho in Neuropsychiatric Systemic Lupus Erythematosus2016

    • Author(s)
      Ichinose K, Ushigusa T, Kawakami A
    • Organizer
      The 60th Annual General Assembly and Scientific Meeting of the Japan Collage of Rheumatology
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-Suprabasin Antibody: Identification of a Novel Antibody for neuropsychiatric systemic lupus erythematosus2016

    • Author(s)
      Ichinose K, Ohyama K, Kawakami A
    • Organizer
      The 60th Annual General Assembly and Scientific Meeting of the Japan Collage of Rheumatology
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 老化抑制遺伝子α-Klothoの中枢神経ループスにおける役割2015

    • Author(s)
      一瀬邦弘、牛草健、佐藤俊太朗、中嶋秀樹、本村政勝、川上純
    • Organizer
      第30回臨床リウマチ学会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Evaluation of Soluble a-Klotho in Neuropsychiatric Systemic Lupus Erythematosus2015

    • Author(s)
      Kunihiro Ichinose, Takeshi Ushigusa, Masataka Umeda, Tomohiro Koga, Atsushi Kawakami, Shuntaro Sato
    • Organizer
      80th American College of Rheumatology(ACR) Annual Meeting
    • Place of Presentation
      San Francisco, CA, USA
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 可溶性α-KlothoのNPSLEにおける意義についての検討2015

    • Author(s)
      一瀬邦弘、牛草健、佐藤俊太朗、中嶋秀樹、本村政勝、川上純
    • Organizer
      第43回 日本臨床免疫学会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Evaluation of Soluble α-Klotho in Neuropsychiatric Systemic Lupus Erythematosus2015

    • Author(s)
      Takeshi Ushigusa, Kunihiro Ichinose, Shuntaro Sato, Atsushi Kawakami
    • Organizer
      16th Annual European Congress of Rheumatology - European League Against Rheumatism
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] マルチプレックスアッセイを用いた中枢神経ループスの治療反応予測因子の検討2015

    • Author(s)
      一瀬邦弘、、有馬和彦、梅田雅孝、福井翔一、西野文子、中島好一、鈴木貴久、 寶來吉朗、古賀智裕、川尻真也、岩本直樹、平井康子、玉井慎美、中村英樹、折口智樹、川上純
    • Organizer
      第59回 日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 可溶性α-KlothoのNPSLEにおける意義についての検討2015

    • Author(s)
      牛草健、一瀬邦弘、辻創介、梅田雅孝、福井翔一、西野文子、中島好一、鈴木貴久、寶來吉朗、川尻真也、岩本直樹、有馬和彦、玉井慎美、中村英樹、折口智樹、川上純
    • Organizer
      第59回 日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Predictors of Therapeutic Outcomes in Patients with Neuropsychiatric Systemic Lupus Erythematosus2014

    • Author(s)
      Kunihiro Ichinose, Takeshi Ushigusa, Yoshikazu Nakashima, Takahisa Suzuki, Yoshiro Horai, Shin-ya Kawashiri, Naoki Iwamoto, Mami Tamai, Kazuhiko Arima, Hideki Nakamura, Tomoki Origuchi and Atsushi Kawakami
    • Organizer
      ACR 2014
    • Place of Presentation
      USA、Boston
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 全身性エリテマトーデスにおけるCaMKIVの役割2014

    • Author(s)
      一瀬邦弘, 古賀智裕, George C. Tsokos, 川上 純
    • Organizer
      第42回 日本臨床免疫学会
    • Place of Presentation
      東京;京王プラザホテル
    • Year and Date
      2014-09-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] ループス腎炎におけるCD86を介したCalcium/calmodulin dependent kinase protein type IVのpodocyte機能に対する影響2014

    • Author(s)
      一瀬邦弘, 牛草健, 川上純
    • Organizer
      第57回 日本腎臓学会学術総会
    • Place of Presentation
      横浜;パシフィコ横浜
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Role of calcium/calmodulin-dependent kinase type IV in podocyte function in lupus nephritis2014

    • Author(s)
      Kunihiro Ichinose, Takeshi Ushigusa, Tomohiro Koga, George C.Tsokos, Atsushi Kawakami
    • Organizer
      EULAR 2014
    • Place of Presentation
      France, Paris
    • Year and Date
      2014-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] ループス腎炎におけるCalcium/calmodulin dependent kinase protein type IV のポドサイト機能に対する影響(第2報)2014

    • Author(s)
      一瀬邦弘, 牛草健, 古賀智裕, George C. Tsokos, 川上 純
    • Organizer
      第58回日本リウマチ学会
    • Place of Presentation
      東京:グランドプリンスホテル新高輪 国際館パミール
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 当院における中枢神経ループスの 治療反応因子の検討2014

    • Author(s)
      一瀬邦弘, 牛草健, 高谷亜由子, 西野文子, 中島好一, 鈴木貴久, 寶來吉朗, 川尻真也, 岩本直樹, 有馬和彦, 玉井慎美, 中村英樹, 折口智樹, 川上 純
    • Organizer
      第58回日本リウマチ学会
    • Place of Presentation
      東京:グランドプリンスホテル新高輪 国際館パミール
    • Year and Date
      2014-04-25
    • Related Report
      2014 Research-status Report
  • [Book] 全身性エリテマトーデス 診断と治療のABC 1182016

    • Author(s)
      一瀬邦弘、川上純
    • Total Pages
      254
    • Publisher
      最新医学社
    • Related Report
      2016 Annual Research Report
  • [Remarks] 長崎大学病院第一内科HP~リウマチ・膠原病グループ

    • URL

      http://www.med.nagasaki-u.ac.jp/intmed-1/group/rheuma.html

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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