The study of bone destruction mechanism of rheumatoid arthritis by synoviolin
| Project/Area Number |
26461478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
YAGISHITA Naoko 聖マリアンナ医科大学, 医学研究科, 講師 (40367389)
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| Co-Investigator(Kenkyū-buntansha) |
荒谷 聡子 東京医科大学, 医学部, 講師 (40387064)
中島 利博 東京医科大学, 医学部, 教授 (90260752)
藤田 英俊 東京医科大学, 医学部, 講師 (90571802)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 遺伝子 / タンパク質 / 動物 / 関節リウマチ / 滑膜細胞 / 小胞体関連分解 / 骨代謝 |
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| Outline of Final Research Achievements |
The symptoms of rheumatoid arthritis (RA) are based on the many processes. We recently cloned Synoviolin as an overexpressing molecule in rheumatoid synovium, and has been verifying its critical roles in RA. In this study, we investigated the role of synoviolin in bone and cartilage using Synoviolin conditional knockout mice and showed that Synoviolin has a crucial role in cartilage.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.2015
Author(s)
Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
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Journal Title
EMBO J.
Volume: 34
Issue: 8
Pages: 1042-55
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] シノビオリン阻害剤の探索。2016
Author(s)
藤田英俊、荒谷聡子、西岡久寿樹、中島利博
Organizer
日本線維筋痛症学会第 8 回学術集会
Place of Presentation
（KFC Hall&Rooms)東京都墨田区
Year and Date
2016-09-17
Related Report
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