| Project/Area Number |
26461486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
玉地 智宏 千葉大学, 大学院医学研究院, 助教 (20456015)
廣瀬 晃一 千葉大学, 大学院医学研究院, 准教授 (90400887)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アレルギー性気道炎症 / 自然リンパ球 / T-bet / 自然型アレルギー性炎症 / IL-33 / 制御性免疫細胞 |
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| Outline of Final Research Achievements |
In this study, we examined the role of Foxp3+ CD3- innate cells and the new mechanism to regulate allergic inflammation.
a) B220, MHC classII, and CCR6 were expressed on Foxp3+ CD3- cells from spleen of hCD2-Foxp3 reporter mice. b) IAIE+ Foxp3+ CD3- cells in the lungs of hCD2-Foxp3 reporter mice were increased after intranasally papain administration. Those results suggest that Foxp3+ CD3- cells were induced in the lungs to regulate allergic airway inflammation without anti-inflammatory cytokine secretion.
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