Asthma and COPD overlap: Elucidation of pathophysiology by molecular approach
| Project/Area Number |
26461489
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Yamaguchi University (2015-2016)
Wakayama Medical University (2014) |
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Principal Investigator |
MATSUNAGA Kazuto 山口大学, 医学(系)研究科(研究院), 教授 (20347602)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 気流制限 / 気道可逆性 / 気道炎症 / リモデリング / サイトカイン / ケモカイン / 成長因子 / ガス分子 / 喘息 / COPD / 気流閉塞 / 軌道過敏性 |
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| Outline of Final Research Achievements |
This study aimed to elucidate the molecular pathology of overlap syndrome of asthma and COPD. Among the inflammation biomarkers assessed, peripheral blood eosinophil count, exhaled NO fraction, exhaled breath condensate IP - 10 increased with asthma and overlap syndrome. It was confirmed that exhaled NO fraction is a useful marker for predicting improvement of airflow limitation and COPD assessment test (CAT) by steroid therapy. It was shown that central expiratory NO and peripheral exhaled NO have equivalent sensitivity and specificity. We also observed that the existence of severe exacerbations and persistently high level of exhaled NO fraction are associated with the rapid progression of airflow limitation in observational studies for asthma.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Stratifying the risk of COPD exacerbation using the modified Medical Reseach Council scale: A multicenter cross-sectional CAP study2015
Author(s)
Matsunaga, K, A. Hayata, K. Akamatsu, T. Hirano, T. Tamada, T. Kamei, T. Tsuda, H. Nakamura, T. Takahashi, S. Hozawa, Y. Mori, Y. Sakamoto, K. Kimura, U. Katsumata, M. Miura, M. Ichinose.
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Journal Title
Respir Investig
Volume: 53
Pages: 82-85
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Progression of Irreversible Airflow Limitation in Asthma: Correlation with Severe Exacerbations.2015
Author(s)
Matsunaga K, Hirano T, Oka A, Tanaka A, Kanai K, Kikuchi T, Hayata A, Akamatsu H, Akamatsu K, Koh Y, Nakanishi M, Minakata Y, Yamamoto N
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Journal Title
J Allergy Clin Immunol Pract.
Volume: 3
Pages: 759-64
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] igarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells2015
Author(s)
K. Kanai, A. Koarai, Y.Shishikura, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata and M.Ichinose.
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Journal Title
Respir Investig
Volume: in press
Pages: 137-148
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] TLR3 Activation Augments Matrix Metalloproteinase Production through Reactive Nitrogen Species Generation in Human Lung Fibroblasts.2015
Author(s)
Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, Oka A, Kanai K, Kawabata H, Hiramatsu M, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Yamamoto N, Ichinose M.
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Journal Title
The Journal of Immnology
Volume: 192
Pages: 4977-4988
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Ongoing allergic rhinitis impairs asthma control by enhancing the lower airway inflammation2014
Author(s)
Oka A, Matsunaga K, Kamei T, Sakamoto Y, Hirano T, Hayata A, Akamatsu K, Kikuchi T, Hiramatsu M, Ichikawa T, Nakanishi M, Minakata Y, Yamamoto N
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Journal Title
The journal of allergy and clinical immunology In practice
Volume: 2
Pages: 172-178
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 呼気NO/EBC2015
Author(s)
松永和人
Organizer
日本アレルギー学会 第2回総合アレルギー講習会
Place of Presentation
パシフィコ横浜（神奈川県横浜市）
Year and Date
2015-12-13
Related Report
Invited
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[Presentation] VBNとEBUS-GSによって診断し得たクリプトコッカス症の二例2015
Author(s)
岡亜早子, 田中彩加, 金井一修, 菊池崇史, 早田敦志, 赤松弘朗, 市川朋宏, 赤松啓一郎, 洪泰浩, 中西正典, 松永和人, 平野綱彦, 中村靖司, 山本信之
Organizer
第38回日本呼吸器内視鏡学会学術集会
Place of Presentation
京王プラザホテル（東京都新宿区）
Year and Date
2015-06-12
Related Report
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[Presentation] 呼気NO測定2015
Author(s)
松永和人
Organizer
第55回日本呼吸器学会学術講演会
Place of Presentation
東京国際フォーラム（東京都千代田区）
Year and Date
2015-04-17
Related Report
Invited
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[Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells2014
Author(s)
Kanai K, Koarai A, Sugiura H, Ichikawa T, Kikuchi T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, and Ichinose M
Organizer
2014 ATS International Conference
Place of Presentation
San Diego, USA
Year and Date
2014-05-22
Related Report
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[Presentation] Changes in forced expiratiry volume in 1 second over time in patients with controlled asthma at baseline.2014
Author(s)
Matsunaga K, Ichikawa T, Oka A, Morishita Y, Kanai K, Hiramatsu M, Akamatsu H, Kawabata H, Kikuchi T, Akamatsu K, Hirano T, Koh Y, Nakanishi M, Minakata Y, Yamamoto N
Organizer
The 54th Annual Meeting of The Japanese Respiratory Society
Place of Presentation
Osaka, Japan
Year and Date
2014-04-27
Related Report
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