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Asthma and COPD overlap: Elucidation of pathophysiology by molecular approach

Research Project

Project/Area Number 26461489
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionYamaguchi University (2015-2016)
Wakayama Medical University (2014)

Principal Investigator

MATSUNAGA Kazuto  山口大学, 医学(系)研究科(研究院), 教授 (20347602)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords気流制限 / 気道可逆性 / 気道炎症 / リモデリング / サイトカイン / ケモカイン / 成長因子 / ガス分子 / 喘息 / COPD / 気流閉塞 / 軌道過敏性
Outline of Final Research Achievements

This study aimed to elucidate the molecular pathology of overlap syndrome of asthma and COPD. Among the inflammation biomarkers assessed, peripheral blood eosinophil count, exhaled NO fraction, exhaled breath condensate IP - 10 increased with asthma and overlap syndrome. It was confirmed that exhaled NO fraction is a useful marker for predicting improvement of airflow limitation and COPD assessment test (CAT) by steroid therapy. It was shown that central expiratory NO and peripheral exhaled NO have equivalent sensitivity and specificity. We also observed that the existence of severe exacerbations and persistently high level of exhaled NO fraction are associated with the rapid progression of airflow limitation in observational studies for asthma.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (59 results)

All 2016 2015 2014

All Journal Article (22 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (27 results) (of which Int'l Joint Research: 8 results,  Invited: 13 results) Book (10 results)

  • [Journal Article] Persistently high exhaled nitric oxide and loss of lung function in controlled asthma2016

    • Author(s)
      Kazuto Matsunaga Tsunahiko Hirano Asako Oka kousuke Ito Nobutaka Edakuni
    • Journal Title

      Allergology International

      Volume: 65 Issue: 3 Pages: 266-271

    • DOI

      10.1016/j.alit.2015.12.006

    • NAID

      130005165877

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differences in physical activity according to mMRC grade in patients with COPD.2016

    • Author(s)
      Hayata A, Minakata Y, Matsunaga K, Nakanishi M, Yamamoto N
    • Journal Title

      International Journal of COPD

      Volume: 11 Pages: 2203-2208

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stratifying the risk of COPD exacerbati on using the modified Medical Research Council scale: A multicenter cross-sectional CAP study.2015

    • Author(s)
      Matsunaga, K, A. Hayata, K. Akamatsu, T. Hirano, T. Tamada, T. Kamei, T. Tsuda, H. Nakamura, T. Takahashi, S. Hozawa, Y. Mori, Y. Sakamoto, K. Kimura, U. Katsumata, M. Miura, M. Ichinose.
    • Journal Title

      Respiratory Investigation

      Volume: 53 Issue: 2 Pages: 82-85

    • DOI

      10.1016/j.resinv.2014.10.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progression of Irreversible Airflow Limitation in Asthma: Correlation with Severe Exacerbations2015

    • Author(s)
      Matsunaga K, Hirano T, Oka A, Tanaka A, Kanai K, Kikuchi T, Hayata A, Akamatsu H, Akamatsu K, Koh Y, Nakanishi M, Minakata Y, Yamamoto N
    • Journal Title

      J Allergy Clin Immunol Pract

      Volume: 3 Issue: 5 Pages: 759-764

    • DOI

      10.1016/j.jaip.2015.05.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Response to Systemic Corticosteroids on Persistently High Exhaled Nitric Oxide in Severe Asthma.2015

    • Author(s)
      Hirano T, Ito K, Edakuni N, Matsunaga K
    • Journal Title

      J Allergy Ther

      Volume: 6 Issue: 04 Pages: 2-4

    • DOI

      10.4172/2155-6121.1000219

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells.2015

    • Author(s)
      K. Kanai, A. Koarai, Y.Shishikura, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata and M.Ichinose.
    • Journal Title

      Respir Investig.

      Volume: in press Issue: 4 Pages: 137-148

    • DOI

      10.1016/j.resinv.2015.01.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of pharmacologic treatment based on airflow limitation and breathlessness on daily physical activity in patients with chronic obstructive pulmonary disease2015

    • Author(s)
      Minakata Y, Morishita Y, Ichikawa T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Ichinose M
    • Journal Title

      Int J Chron Obstruct Pulmon Dis

      Volume: 10 Pages: 1275-1282

    • DOI

      10.2147/copd.s84134

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biomarker-based detection of ACOS in COPD populations.2015

    • Author(s)
      Tamada, T., H. Sugiura, T. Takahashi, K. Matsunaga, K. Kimura, U. Katsumata, D. Takekoshi, T. Kikuchi, K. Ohta and M. Ichinose.
    • Journal Title

      Int J Chron Obstruct Pulmon Di

      Volume: 10 Pages: 2169-2176

    • DOI

      10.2147/copd.s88274

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] チオトロピウム(喘息に対する適応拡大)2015

    • Author(s)
      早田敦志, 松永和人
    • Journal Title

      分子呼吸器病

      Volume: 19 Pages: 83-85

    • Related Report
      2015 Research-status Report
  • [Journal Article] 呼気中一酸化窒素、一酸化炭素の有用性と課題2015

    • Author(s)
      平野綱彦, 松永和人
    • Journal Title

      アレルギー・免疫

      Volume: 22 Pages: 30-39

    • Related Report
      2015 Research-status Report
  • [Journal Article] 喘息の疫学:特に高齢者喘息における現状と問題点2015

    • Author(s)
      松永和人
    • Journal Title

      PROGRESS IN MEDICINE

      Volume: 35 Pages: 1533-1539

    • Related Report
      2015 Research-status Report
  • [Journal Article] 呼吸機能検査2015

    • Author(s)
      平野綱彦, 松永和人
    • Journal Title

      アレルギーの臨床

      Volume: 35 Pages: 27-30

    • Related Report
      2015 Research-status Report
  • [Journal Article] 難治性喘息におけるTNF-LIGHTの意義2015

    • Author(s)
      平野綱彦, 松永和人
    • Journal Title

      アレルギーの臨床

      Volume: 35 Pages: 42-43

    • Related Report
      2015 Research-status Report
  • [Journal Article] Ongoing Allergic Rhinitis Impairs Asthma Control by Enhancing the Lower Airway Inflammation2014

    • Author(s)
      Oka A, Matsunaga K, Kamei T, Sakamoto Y, Hirano T, Hayata A, Akamatsu K, Kikuchi T, Hiramatsu M, Ichikawa T, Nakanishi M, Minakata Y, Yamamoto N
    • Journal Title

      J Allergy Clin Immunol Pract

      Volume: 2 Issue: 2 Pages: 172-178

    • DOI

      10.1016/j.jaip.2013.09.018

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts.2014

    • Author(s)
      Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, Oka A, Kanai K, Kawabata H, Hiramatsu M, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Yamamoto N, Ichinose M.
    • Journal Title

      J Immunol

      Volume: 192 Issue: 11 Pages: 4977-4988

    • DOI

      10.4049/jimmunol.1302919

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in forced expiratory volume in 1 second over time in patients with controlled asthma at baseline2014

    • Author(s)
      Kazuto Matsunaga
    • Journal Title

      Respiratory Medicine

      Volume: 108 Issue: 7 Pages: 976-982

    • DOI

      10.1016/j.rmed.2014.04.014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feasibility of Flying Disc Game for Patients with Oxygen Therapy.2014

    • Author(s)
      4.Honda Y, Minakata Y, Morishita Y, Sugino A, Hayata A, Ichikawa T, Nakanishi M, Matsunaga K, Yamamoto N
    • Journal Title

      Clin Rse Pulmonol

      Volume: 2 Pages: 1024-1024

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ステロイド薬使用に伴う副作用とその対策2014

    • Author(s)
      佐野綾香, 平野綱彦, 松永和人
    • Journal Title

      呼吸

      Volume: 33 Pages: 360-364

    • Related Report
      2014 Research-status Report
  • [Journal Article] 気道過敏性検査2014

    • Author(s)
      松永和人
    • Journal Title

      Repiratory Medical Research

      Volume: 2 Pages: 51-54

    • Related Report
      2014 Research-status Report
  • [Journal Article] 鼻炎合併喘息におけるコントロール不良の規定因子2014

    • Author(s)
      松永和人
    • Journal Title

      アレルギーの臨床

      Volume: 34 Pages: 85-88

    • Related Report
      2014 Research-status Report
  • [Journal Article] 喘息発作時のテオフィリン薬使用の是非について Conの立場から2014

    • Author(s)
      早田敦志 松永和人
    • Journal Title

      喘息

      Volume: 27 Pages: 95-98

    • Related Report
      2014 Research-status Report
  • [Journal Article] 気道閉塞の変動性とその臨床評価2014

    • Author(s)
      早田敦志 松永和人
    • Journal Title

      アレルギー・免疫

      Volume: 21 Pages: 23-30

    • Related Report
      2014 Research-status Report
  • [Presentation] FeNOと抗炎症治療2016

    • Author(s)
      松永和人
    • Organizer
      第26回国際喘息学会日本・北アジア部会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Survival from acute exacerbation of idiopathic pulmonary fibrosis with or without direct hemoperfusion with polymyxin B-immobilized fiber column:A retrospective analysis.2016

    • Author(s)
      Keiji Oishi, Keisuke Aoe, Yusuke Mimura, Yoriyuki Murata, Kenji Sakamoto, Wataru Koutoku, Tsuneo Matsumoto, Hiroshi Ueoka, Kazuto Mastunaga, Masafumi Yano.
    • Organizer
      ERS INTERNATIONAL CONGRESS 2016
    • Place of Presentation
      LONDON(United Kingdom)
    • Year and Date
      2016-09-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cross-talk between TNF-LIGHT and nitrosative stress in the airway remodeling of asthma.2016

    • Author(s)
      Tsunahiko Hirano, Kosuke Ito, Nobutaka Edakuni, Kazuto Matsunaga
    • Organizer
      ERS INTERNATIONAL CONGRESS 2016
    • Place of Presentation
      LONDON(United Kingdom)
    • Year and Date
      2016-09-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] One airway one diseaseと炎症性メディエーター:脂質メディエーターを中心に2016

    • Author(s)
      松永和人
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Enhancement to asthma management efficiency by FeNO measurement.2016

    • Author(s)
      Kazuto Matsunaga
    • Organizer
      The 9th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
    • Place of Presentation
      SENDAI INTERNATIONAL CENTER(宮城県仙台市)
    • Year and Date
      2016-05-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 呼気NOによる喘息モニタリングの意義2016

    • Author(s)
      松永和人
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-10
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 喘息気道のリモデリング進展は防止できるか?2016

    • Author(s)
      松永和人
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-09
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 病像・病態からみた高齢者喘息2016

    • Author(s)
      松永和人
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-08
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] COPD:個別化治療の重要性2015

    • Author(s)
      松永和人
    • Organizer
      第54回日本呼吸器学会中国・四国地方会
    • Place of Presentation
      くにびきメッセ(島根県松江市)
    • Year and Date
      2015-12-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 呼気NO/EBC2015

    • Author(s)
      松永和人
    • Organizer
      日本アレルギー学会 第2回総合アレルギー講習会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-12-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] COPDにおける気道炎症評価の意義2015

    • Author(s)
      松永和人
    • Organizer
      第75回日本呼吸器学会・日本結核病学会・日本サルコイドーシス/肉芽腫性疾患学会 九州支部 秋季学術講演会
    • Place of Presentation
      ホテルグランデはがくれ(佐賀県佐賀市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Clinical Application of Exhaled NO Measurements in COPD.2015

    • Author(s)
      Matsunaga K
    • Organizer
      The 25th Congress of Interasma Japan/North Asia
    • Place of Presentation
      ホテルニューグランド(神奈川県横浜市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 高齢進行期胸部悪性腫瘍患者においてGFR値を予測する新たな推算式の検討2015

    • Author(s)
      菊池崇史, 赤松弘朗, 盛啓太, 金井一修, 赤松啓一郎, 洪泰浩, 中西正典, 松永和人, 上田弘樹, 山本信之
    • Organizer
      第13回日本臨床腫瘍学会学術集会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2015-07-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 喘息治療の進歩と今後の課題2015

    • Author(s)
      松永和人
    • Organizer
      第115回日本結核病学会近畿地方会 第85回日本呼吸器学会近畿地方会
    • Place of Presentation
      奈良県文化会館(奈良県奈良市)
    • Year and Date
      2015-07-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] VBNとEBUS-GSによって診断し得たクリプトコッカス症の二例2015

    • Author(s)
      岡亜早子, 田中彩加, 金井一修, 菊池崇史, 早田敦志, 赤松弘朗, 市川朋宏, 赤松啓一郎, 洪泰浩, 中西正典, 松永和人, 平野綱彦, 中村靖司, 山本信之
    • Organizer
      第38回日本呼吸器内視鏡学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
  • [Presentation] PERSISTENTLY HIGH EXHALED NITRIC OXIDE AND LUNG FUNCTION DECLINE IN PATIENTS WITH CONTROLLED ASTHMA AT BASELINE.2015

    • Author(s)
      Matusnaga K
    • Organizer
      The 64th Meeting of Japanese Society of Allergology
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Statifying the risk of COPD exacerbation using the modified Medical Research Council scale: a multicenter cross-sectional CAP study.2015

    • Author(s)
      Matsunaga K, Oka A, Hayata A, Akamtsu K, Hirano T, Ichinose M
    • Organizer
      2015 ATS International Conference
    • Place of Presentation
      Denver, USA
    • Year and Date
      2015-05-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of Inhaled Short-Acting Bate-2 Agonist (Procaterol) on Physical Activity of Patients with Chronic Obstructive Pulmonary disease.2015

    • Author(s)
      Hirano T, Matsunaga K, Ogawa H, Minakata Y, Akamatsu K, Nakanishi M, Ichikawa T, Ichinose M
    • Organizer
      2015 ATS International Conference
    • Place of Presentation
      Denver, USA
    • Year and Date
      2015-05-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Establishment of multiplexed ultra-sensitive detection of epidermal growth factor receptor mutations using picodroplet digital PCR.2015

    • Author(s)
      Akamatsu H, Koh Y, Watanabe M, Kikuchi T, Nakanishi M, Matsunaga K, Yamamoto N
    • Organizer
      American Association for Cancer Research Annual Meeting 2015
    • Place of Presentation
      Philadelphia, Pennsylvania, USA
    • Year and Date
      2015-04-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 呼気NO測定2015

    • Author(s)
      松永和人
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 当院気管支鏡検査における迅速細胞診(Rapid on-site evaluation ; ROSE)の検討2015

    • Author(s)
      金井一修, 赤松弘朗, 松本安子, 田中彩加, 菊池崇史, 洪泰浩, 中西正典, 松永和人, 平野綱彦, 山本信之
    • Organizer
      第112回日本内科学会講演会
    • Place of Presentation
      みやこめっせ(京都府左京区)
    • Year and Date
      2015-04-11
    • Related Report
      2015 Research-status Report
  • [Presentation] ASSOCIATION OF SEVERE EXACERBATION WITH FEV1 DECLINE AND LOSS OF AIRWAY REVERSIBILITY ASTHMA2014

    • Author(s)
      Matsunaga K, Ichikawa T, Akamatsu K, Hirano T
    • Organizer
      2014 ERS International Congress
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2014-09-06 – 2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] PERSISTENTLY HIGH EXHALED NITRIC OXIDE AND LUNG FUNCTION DECLINE IN PATIENTS WITH CONTROLLED ASTHMA AT BASELINE2014

    • Author(s)
      Matsunaga K, Ichikawa T, Akamatsu K, Hirano T
    • Organizer
      2014 ERS International Congress
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2014-09-06 – 2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Cigarette smoke augments MUC5AC mucin production via TLR3-EGFR pathway in airway epithelial cells2014

    • Author(s)
      Kanai K, Koarai A, Sugiura H, Ichikawa T, Kikuchi T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, and Ichinose M
    • Organizer
      2014 ATS International Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 高齢者喘息の診断と治療: アップデート2014

    • Author(s)
      松永和人
    • Organizer
      第26回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 長期管理中の喘息患者における気道閉塞の進展:重症増悪の影響2014

    • Author(s)
      松永和人, 岡亜早子, 市川朋宏, 平野綱彦, 赤松啓一郎, 中西正典
    • Organizer
      第26回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Changes in forced expiratiry volume in 1 second over time in patients with controlled asthma at baseline.2014

    • Author(s)
      Matsunaga K, Ichikawa T, Oka A, Morishita Y, Kanai K, Hiramatsu M, Akamatsu H, Kawabata H, Kikuchi T, Akamatsu K, Hirano T, Koh Y, Nakanishi M, Minakata Y, Yamamoto N
    • Organizer
      The 54th Annual Meeting of The Japanese Respiratory Society
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2014-04-27
    • Related Report
      2014 Research-status Report
  • [Book] 喘息・COPD・ACOSの鑑別はどう進める? もう悩まない!喘息・COPD・ACOSの外来診療2016

    • Author(s)
      松永和人
    • Total Pages
      205
    • Publisher
      羊土社
    • Related Report
      2016 Annual Research Report
  • [Book] COPD・ACOS関連疾患. もう悩まない!喘息・COPD・ACOSの外来診療2016

    • Author(s)
      松永和人
    • Total Pages
      205
    • Publisher
      羊土社
    • Related Report
      2016 Annual Research Report
  • [Book] COPD(慢性閉塞性肺疾患). 今日の診療のためにガイドライン外来診療20162016

    • Author(s)
      大石景士, 松永和人
    • Total Pages
      605
    • Publisher
      日経メディカル開発
    • Related Report
      2016 Annual Research Report
  • [Book] 喘息:呼気NO測定の活用法. 内科INTERNAL 122016

    • Author(s)
      大石景士, 松永和人
    • Total Pages
      1181
    • Publisher
      南江堂
    • Related Report
      2016 Annual Research Report
  • [Book] 呼気検査. アレルギーの疾患のすべて2016

    • Author(s)
      松永和人
    • Total Pages
      366
    • Publisher
      日本医師会雑誌
    • Related Report
      2016 Annual Research Report
  • [Book] 新しい検査:呼気一酸化窒素測定、呼吸器疾患診療の最先端2015

    • Author(s)
      松永和人
    • Total Pages
      502
    • Publisher
      先端医療技術研究所
    • Related Report
      2015 Research-status Report
  • [Book] 薬物によるコントロール・段階的薬剤投与プラン 喘息予防・管理ガイドライン20152015

    • Author(s)
      松永和人
    • Total Pages
      317
    • Publisher
      協和企画
    • Related Report
      2015 Research-status Report
  • [Book] Oxidative stress and respiratory muscle dysfunction. Studies on Respiratory Disorders.2014

    • Author(s)
      Matsunaga K, Minakata Y
    • Total Pages
      394
    • Publisher
      Humana Press
    • Related Report
      2014 Research-status Report
  • [Book] 呼気NO. 呼吸機能検査テキスト 原理、測定法の実際から臨床例まで2014

    • Author(s)
      松永和人
    • Total Pages
      88
    • Publisher
      呼吸研究
    • Related Report
      2014 Research-status Report
  • [Book] 気管支喘息. 呼吸機能検査テキスト 原理、測定法の実際から臨床例まで2014

    • Author(s)
      松永和人
    • Total Pages
      88
    • Publisher
      呼吸研究
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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