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The effect of influenza vaccination on whole-genome analysis

Research Project

Project/Area Number 26461505
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionKyushu University

Principal Investigator

Chong Yong  九州大学, 医学研究院, 助教 (60721264)

Co-Investigator(Kenkyū-buntansha) 池松 秀之  九州大学, 大学病院, 学術研究員 (30521182)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsインフルエンザ / 抗原変異 / ワクチン
Outline of Final Research Achievements

The effect of vaccination on the dynamics of influenza virus variants remains largely unknown in humans. We compared influenza hemagglutinin (HA) gene sequences isolated from vaccinated and unvaccinated populations with the yearly vaccine strains. In total, 181 influenza A/H3N2 virus samples isolated from 82 vaccinated and 99 unvaccinated patients (2011-15, four Japanese influenza seasons) were genetically analyzed using a NGS. Amino acid (AA) differences from corresponding vaccine strains were found in 74 of 329 HA1 sites. There was a maximum of four AA differences within the epitopes in the former three seasons (2011-14) and fifteen in the latter season (2014-15). Deviation to a greater number of AA differences was found more significantly in the isolates from vaccinated patients as compared to unvaccinated patients. Our data first suggested that in humans, immune pressure induced by vaccination works to select influenza variants genetically distant from vaccine strains.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Effect of seasonal vaccination on the selection of influenza A/H3N2 epidemic variants2017

    • Author(s)
      Yong Chong, Hideyuki Ikematsu
    • Journal Title

      Vaccine

      Volume: 35 Issue: 2 Pages: 255-263

    • DOI

      10.1016/j.vaccine.2016.11.084

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 2011/12, 2012/13年流行期に患者より分離されたインフルエンザA/H3N2型96株のNA遺伝子におけるHA遺伝子との関連性についての検討2016

    • Author(s)
      鄭 湧
    • Organizer
      日本感染症学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 2011/12及び2012/13年流行期に患者より分離されたインフルエンザA/H3N2型ウイルス96株のHA遺伝子の検討2015

    • Author(s)
      鄭 湧
    • Organizer
      日本感染症学会総会
    • Place of Presentation
      京都
    • Year and Date
      2015-04-16 – 2015-04-17
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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