Spontaneous clearance of Hepatitis C virus infection

• Project/Area Number: 26461506
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Kyushu University
• Principal Investigator: Norihiro Furusyo 九州大学, 医学研究院, 准教授 (10346786)
• Co-Investigator(Kenkyū-buntansha): 村田 昌之 九州大学, 大学病院, 講師 (60380622) ; 小川 栄一 九州大学, 医学研究院, 助教 (70621283)
• Research Collaborator: IKEZAKI Hiroaki ; HIRAMINE Satoshi
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: Hepatitis C virus / Interleukin 28B / Spontaneous clearance / Japanese population / African Americans / 一般住民 / C型肝炎ウイルス / 持続感染 / 自然排除 / インターロイキン28B遺伝子 / C型慢性肝炎 / ウイルス自然排除 / TA repeat / インターロイキン28B / ウイルス血症消失

Outline of Final Research Achievements

Hepatitis C virus (HCV) infection is a serious global health problem. Genome-wide association studies have revealed several single-nucleotide polymorphisms around
interleukin 28B (IL28B) that are strongly associated with HCV clearance by antiviral treatment. Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in the Japanese population. A long TA repeat in the promoter region ofIL28B was also associated with spontaneous HCV clearance. Although its efficacy may be limited in Japanese population because of its allele distribution, this novel genetic factor will be useful for predicting HCV clearance especially for the African Americans.

Research Products

• [Int'l Joint Research] Baltimore, MD 21205/Division of Infectious Diseases/Johns Hopkins School of Medicine,(米国)
• [Journal Article] Association of IL28B rs8099917 genotype and female sex with spontaneous clearance of hepatitis C virus infection: a Japanese cross-sectional study. (2016)
  • Author(s): Ikezaki H, Furusyo N, Hiramine S, Ura K, Mitsumoto-Kaseida F, Takayama K, Shimizu M, Toyoda K, Ogawa E, Kainuma M, Murata M, Hayashi J.
  • Journal Title: Archives of Virology Volume: 161 (3) Issue: 3 Pages: 641-648
  • DOI: 10.1007/s00705-015-2703-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A thymine-adenine dinucleotide repeat polymorphism near IL28B is associated with spontaneous clearance of hepatitis C virus. (2016)
  • Author(s): Hiramine S, Sugiyama M, Furusyo N, Uto H, Ido A, Tsubouchi H, Watanabe H, Ueno Y, Korenaga M, Murata K, Masaki N, Hayashi J, Thomas DL, Mizokami M.
  • Journal Title: Journal of Gastroenterology Volume: 50 Issue: 10 Pages: 1069-1077
  • DOI: 10.1007/s00535-015-1056-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hepatitis B Virus-related Immune Reconstitution Inflammatory Syndrome in Two Patients Coinfected with Human Immunodeficiency Virus Diagnosed with a Liver Biopsy (2014)
  • Author(s): Mitsumoto F, Murata M, Kato Y, Ura K, Takayama K, Hiramine S, Ikezaki H, Shimizu M, Toyoda K, Ogawa E, Aishima S, Furusyo N, Hayashi J.
  • Journal Title: Internal Medicine Volume: 53 Issue: 18 Pages: 2165-2170
  • DOI: 10.2169/internalmedicine.53.2503
  • NAID: 130004687659
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Filaggrin loss-of-function mutations are not a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate. (2014)
  • Author(s): Sasaki T, Furusyo N, Shiohama A, Takeuchi S, Nakahara T, Uchi H, Hirota T, Tamari M, Shimizu N, Ebihara T, Amagai M, Furue M, Hayashi J, Kudoh J.
  • Journal Title: Journal of Dermatolgical Sciences Volume: 76(1) Issue: 1 Pages: 10-15
  • DOI: 10.1016/j.jdermsci.2014.06.004
  • Peer Reviewed
• [Journal Article] Nocturnal Difference in the Ultra Low Frequency Band of Heart Rate Variability in Patients Stratified by Kampo Medicine Prescription (2014)
  • Author(s): Kainuma M, Furusyo N, Ando S, Mukae H, Ogawa E, Toyoda K, Murata M, Hayashi J.
  • Journal Title: Circulation Journal Volume: 78 Issue: 8 Pages: 1924-1927
  • DOI: 10.1253/circj.CJ-14-0362
  • NAID: 130004926991
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Efficacy and safety of splenectomy in telaprevir-based triple therapy for chronic hepatitis C patients with thrombocytopenia and advanced fibrosis. (2014)
  • Author(s): Ogawa E, Furusyo N, Nakamuta M, Kajiwara E, Nomura H, Dohmen K, Takahashi K, Satoh T, Azuma K, Kawano A, Tanabe Y, Kotoh K, Shimoda S, Akahoshi T, Maehara Y, Hayashi J; Kyushu University Liver Disease Study (KULDS) Group.
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 29(9) Issue: 9 Pages: 1728-1735
  • DOI: 10.1111/jgh.12619
  • Peer Reviewed
• [Journal Article] Influence of low-density lipoprotein cholesterol on virological response to telaprevir-based triple therapy for chronic HCV genotype 1b infection. (2014)
  • Author(s): Ogawa E, Furusyo N, Kajiwara E, Nomura H, Dohmen K, Takahashi K, Nakamuta M, Satoh T, Azuma K, Kawano A, Tanabe Y, Kotoh K, Shimoda S, Hayashi J; Kyushu University Liver Disease Study (KULDS) Group.
  • Journal Title: Antiviral Research Volume: 104 Pages: 102-109
  • DOI: 10.1016/j.antiviral.2014.01.004
  • Peer Reviewed
• [Journal Article] Therapeutic drug monitoring of telaprevir in chronic hepatitis C patients receiving telaprevir-based triple therapy is useful for predicting virological response. (2014)
  • Author(s): Furusyo N, Ogawa E, Murata M, Toyoda K, Ohnishi H, Eiraku K, Shimizu M, Harada Y, Mitsumoto F, Takayama K, Kainuma M, Okada K, Hayashi J.
  • Journal Title: Journal of Antimicrobilal Chemotherapy Volume: 69(2) Issue: 2 Pages: 483-490
  • DOI: 10.1093/jac/dkt371
  • Peer Reviewed
• [Presentation] DAAs: What do we have and How do we choose ? (2016)
  • Author(s): Furusyo N.
  • Organizer: The Hong Kong Association for the Study of Liver Diseases 29th Annual Scientific Meeting and International Symposium on Hepatology 2016
  • Place of Presentation: Hong Kong
  • Year and Date: 2016-11-20
  • Int'l Joint Research / Invited
• [Presentation] Practical tips on drug-drug interaction and resistance (2016)
  • Author(s): Furusyo N.
  • Organizer: The Hong Kong Association for the Study of Liver Diseases 29th Annual Scientific Meeting and International Symposium on Hepatology 2016
  • Place of Presentation: Hong Kong
  • Year and Date: 2016-11-20
  • Int'l Joint Research / Invited
• [Presentation] C型肝炎ウイルス自然排除とインターロイキン28B遺伝子プロモーター領域のTA repeatの関連の検討 (2014)
  • Author(s): 平峯 智、古庄憲浩、光本富士子、髙山耕治、 浦 和也、志水元洋、豊田一弘、小川栄一、 貝沼茂三郎、村田昌之、溝上雅史、林 純
  • Organizer: 第88回日本感染症学会学術講演会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-06-18 – 2014-06-20