| Project/Area Number |
26461506
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村田 昌之 九州大学, 大学病院, 講師 (60380622)
小川 栄一 九州大学, 医学研究院, 助教 (70621283)
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| Research Collaborator |
IKEZAKI Hiroaki
HIRAMINE Satoshi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Hepatitis C virus / Interleukin 28B / Spontaneous clearance / Japanese population / African Americans / 一般住民 / C型肝炎ウイルス / 持続感染 / 自然排除 / インターロイキン28B遺伝子 / C型慢性肝炎 / ウイルス自然排除 / TA repeat / インターロイキン28B / ウイルス血症消失 |
|---|
| Outline of Final Research Achievements |
Hepatitis C virus (HCV) infection is a serious global health problem. Genome-wide association studies have revealed several single-nucleotide polymorphisms around
interleukin 28B (IL28B) that are strongly associated with HCV clearance by antiviral treatment. Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in the Japanese population. A long TA repeat in the promoter region ofIL28B was also associated with spontaneous HCV clearance. Although its efficacy may be limited in Japanese population because of its allele distribution, this novel genetic factor will be useful for predicting HCV clearance especially for the African Americans.
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