| Project/Area Number |
26461508
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
KOHNO Shigeru 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (80136647)
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| Co-Investigator(Kenkyū-buntansha) |
泉川 公一 長崎大学, 医歯薬学総合研究科(医学系), 教授 (20404212)
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| Research Collaborator |
SAIJO Tomomi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | クリプトコック髄膜炎 / 抗GM-CSF抗体 / クリプトコックス抗原 / 肺クリプトコックス症 / BALF中クリプトコックス抗原 / クリプトコックス症 / MLST / 病原性評価 / 中枢神経クリプトコックス症 / Cryptococcus neoformans / Cryptococcus gattii / GM-CSF / STAT5 / 抗GM-CSF自己抗体 |
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| Outline of Final Research Achievements |
Cryptococcus is a pathogenic yeast which causes serious invasive fungal disease not only in immunocompromised patients but also in immunocompetent patients, while the mechanism of the development of cryptococcosis in terms of both fungal virulence factors and host defense systems have much remained unknown. Although detection of cryptococcal glucuronoxylomannan (GXM) antigen in the serum and/or in the cerebrospinal fluid is a useful method for the diagnosis of cryptococcosis, GXM antigen in the serum sometimes remains negative in a patient with a small lesion of pulmonary cryptococcosis.
We evaluated that anti GM-CSF auto antibodies in the host serum are associated with the development of cryptococcal meningitis. The rate of GXM-positive BALF samples was higher than the rate for serum samples, especially for patients with pulmonary lesion diameters <25 mm.
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