| Project/Area Number |
26461514
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
Wada Hiroo 順天堂大学, 医学(系)研究科(研究院), 准教授 (50407053)
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Hajime 杏林大学, 医学部, 教授 (80134617)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | COPD / 環境曝露 / 呼吸器病学 / 動物モデル / 喫煙 / IL-17 / redundancy / MMP-9 / 好中球 / マウス |
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| Outline of Final Research Achievements |
The role of IL-17 in an inflammatory reaction to cigarette smoke exposure was investigated, using IL-17 deficient mice. IL-17 deficient mice showed that neutrophilic inflammation was restored in short-term exposure, and subsequently that the emphysematous change was restored after long-term exposure, in comparison with the wild-type mice. This suggested that IL-17 plays a crucial role in an inflammatory reaction to cigarette smoke exposure, and thus a possible molecular target in the therapeutic strategies to cigarette-smoke associated airway disorder, such as COPD.
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