The suppressive effect of breast feeding on the progression of obesity: the combined action in adipocytes and gut endocrine cells
| Project/Area Number |
26461524
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
FUJISAWA YASUKO 浜松医科大学, 医学部附属病院, 講師 (40402284)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脂肪細胞 / 母乳 / PUFA / SCD1 / リポジェネティック遺伝子 / 長鎖不飽和脂肪酸 / リポジェニック酵素 / 腸管細胞 / 相乗効果 / 長鎖脂肪酸 / 乳児栄養 / リポジェニック遺伝子 / PPARγ / 脂肪酸 / SCD１ |
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| Outline of Final Research Achievements |
In this study, we focus on the major polyunsaturated fatty acids(PUFAs) in human breast milk: linoleic acid(LA), alpha-linolenic acid (ALA), arachidonic acid (AA), and docosahexaenoic acid (DHA) in views of the effect of breast feeding on the lipid metabolism in baby. All experiments were performed using 3T3-L1 adipocyte cell line. Our results are as follows: 1. All PUFA (LA ALA AA and DHA) suppressed the gene expression of SCD1 gene. SCD1 is the lipogenic gene and the suppression of SCD1 could inhibit the progression to metabolic disorders including insulin resistance, diabetes and metabolic syndrome. 2. the mixture of multiple PUFA (e.g. LA and AA, or ALA and AA) suppressed SCD1 gene expression synergistically3 Some part of the suppressive effect by PUFAs is depend in PPARg pathway. We plan to proceed comprehensive gene expression analysis and lipidomic studies analysis to figure out the mechanism of PUFA induced SCD1 suppression.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] FGFR1 Analyses in Four Patients with Hypogonadotropic Hypogonadism with Split-Hand/Foot Malformation: Implications for the Promoter Region.2017
Author(s)
Ohtaka K, Fujisawa Y, Takada F, Hasegawa Y, Miyoshi T, Hasegawa T, Miyoshi H, Kameda H, Kurokawa-Seo M, Fukami M, Ogata T.
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Journal Title
Hum Mutat.
Volume: 38
Issue: 5
Pages: 503-506
DOI
Related Report
Peer Reviewed
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[Journal Article] Urinary myo-inositol levels in Japanese schoolchildren with normal glucose tolerance.2016
Author(s)
Satake E, Matsushita R, Kitsuda K, Ohtaka K, Nagata E, Yamaguchi R, Sano S, Fujisawa Y, Nakanishi T, Nakagawa Y, Ohzeki T.
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Journal Title
J Pediatr Endocrinol Metab
Volume: 29
Issue: 2
Pages: 179-184
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Development of waist circumference percentiles for Japanese children and an examination of their screening utility for childhood metabolic syndrome: a population-based cross-sectional study.2015
Author(s)
Matsushita R, Isojima T, Takaya R, Satake E, Yamaguchi R, Kitsuda K, Nagata E, Sano S, Nakanishi T, Nakagawa Y, Ohzeki T, Ogata T, Fujisawa Y.
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Journal Title
BMC Public Health
Volume: 13
Issue: 1
Pages: 1121-1121
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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