Evaluation of blood myokine levels in obese childre with metabolic symdrome
| Project/Area Number |
26461535
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
荒木 俊介 産業医科大学, 医学部, 助教 (20515481)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 小児肥満 / メタボリックシンドローム / マイオカイン / IL-6 / アイリシン / ＩＬ－６ / 小児メタボリックシンドローム / ケモカイン / 内臓脂肪面積 / ビタミンＤ / 腹囲 / 尿酸 |
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| Outline of Final Research Achievements |
We investigated the relationship between serum IL-6 and irisin levels, anthropometries and MS-related components in Japanese obese children. 85 obese Japanese children were enrolled. The relationship between serum IL-6 and irisin levels and anthropometries, MS-related components were evaluated. Among 85 obese children, 37 were diagnosed as morbidly obese. The serum IL-6 and irisin levels were decreased in morbidly obese group, compared with mild to moderate obese group, but not significant. Among 85 obese children, 30 were diagnosed as MS. The serum levels of IL-6 and irisin levels were decreased in MS group, compared with non-MS, but not significant. By univariate linear regression analysis, serum levels of IL-6 were positively correlated with AST, ALT and inversely positively correlated with apoA1. Serum levels of myokines, might be associated with development of MS in obese children. Further investigation will be needed.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] Postnatal changes in skin water content in preterm infants2015
Author(s)
Ishiguro A, Fujinuma S, Motojima Y, Oka S, Komaki T, Saito A, Kawasaki H, Araki S, Kanai M, Sobajima H, Tamura M
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Journal Title
Early Hum Dev
Volume: 91
Issue: 9
Pages: 505-509
DOI
Related Report
Peer Reviewed
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[Journal Article] Mutation spectrum and phenotypic variation in nine patients with SOX2 abnormalities2014
Author(s)
Suzuki J, Azuma N, Dateki S, Soneda S, Muroya K, Yamamoto Y, Saito R, Sano S, Nagai T, Wada H, Endo A, Urakami T, Ogata T, Fukami M
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Journal Title
J Hum Genet
Volume: 59
Pages: 353-356
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Molecular and clinical characterization of glucokinase maturity-onset diabetes of the young (GCK-MODY) in Japanese patients.2014
Author(s)
Kawakita R, Hosokawa Y, Fujimaru R, Tamagawa N, Urakami T, Takasawa K, Moriya K, Mizuno H, Maruo Y, Takuwa M, Nagasaka H, Nishi Y, Yamamoto Y, Aizu K, Yorifuji T.
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Journal Title
Diabet Med
Volume: mar
Issue: 11
Pages: 17-17
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] A variety of clinical presentation in congenital hypothyroidism caused by mutations in the thyroglobulin gene2016
Author(s)
Kawakita A, Yamamoto Y, Kubo K, Eguchi M, Saito R, Goto M, Kawagoe R, Kawada Y, Kusuhara K, Narumi S, Hasegawa T
Organizer
The 9th Biennial Scientific Meeting of the Asia Pacific Paediatric Endocrine Society/ The 50th Annual Meeting of the Japanese Society for Pediatric Endocrinology
Place of Presentation
Tokyo International Forum (東京都・千代田区)
Year and Date
2016-11-16
Related Report
Int'l Joint Research
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[Presentation] Two brothers with ATRX mutation having micropenis without other features of ATR-X syndrome2016
Author(s)
Eguchi M, Yamamoto Y, Saito R, Goto M, Araki S, Kubo K, Kawagoe R, Kawada Y, Kusuhara K, Sato T, Narumi S, Hasegawa T
Organizer
The 9th Biennial Scientific Meeting of the Asia Pacific Paediatric Endocrine Society/ The 50th Annual Meeting of the Japanese Society for Pediatric Endocrinology
Place of Presentation
Tokyo International Forum (東京都・千代田区)
Year and Date
2016-11-16
Related Report
Int'l Joint Research
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[Presentation] Peripheral administration of glucagon-like peptide-1and cholecystokinin-8 activates nesfatin-1-containing neurons in the hypothalamus and brainstem of rats2015
Author(s)
Yamamoto Y, Saito R, So M, Motojima Y, Matsuura T, Yoshimura M, Hashimoto H, Kusuhara K, Ueta Y
Organizer
Neuroscience meeting 2015
Place of Presentation
Chicago Convention Center, Chicago, IL, USA
Year and Date
2015-10-17
Related Report
Int'l Joint Research
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[Presentation] Milk deprivation and refeeding during preweaning period alter galanin like peptide gene expression in the posterior pituitary2015
Author(s)
Goto M, Yamamoto Y, Kubo K, Ishii M, Saito R, Araki S, Kawagoe R, Kawada Y, Kusuhara K
Organizer
The 8th Asia-Oceania Conference on Obesity
Place of Presentation
Nagoya International Convention Center, Nagoya, Japan
Year and Date
2015-10-02
Related Report
Int'l Joint Research
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[Presentation] The effect of milk deprivation and refeeding on galanin-like peptide gene expression in neural lobe of rat pituitary2015
Author(s)
Goto M, Yamamoto Y, Kazuyasu K, Ishii M, Saito R, Araki S, Kawagoe K, Kawada Y, Kusuhara K
Organizer
The 11th Congress of Asian Society for Pediatric Research
Place of Presentation
Osaka International convention center, Osaka , Japan
Year and Date
2015-04-15
Related Report
Int'l Joint Research
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[Presentation] Galanin like peptide gene expression in neural lobe of rat pituitary; effect of milk deprivation and refeeding2014
Author(s)
Goto M, Yamamoto Y, Kubo K, Ishii M, Saito R, Araki S, Kawagoe R,Kawada Y, Kusuhara K
Organizer
Neuroscience 2014,the Society’s 44th annual meeting
Place of Presentation
Washington Convention Center, Washington DC, USA
Year and Date
2014-11-15 – 2014-11-20
Related Report
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