| Project/Area Number |
26461543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
早川 昌弘 名古屋大学, 医学部附属病院, 病院教授 (40343206)
夏目 淳 名古屋大学, 医学系研究科, 寄附講座教授 (60422771)
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| Research Collaborator |
OGAWA Chikako 名古屋大学, 医学部附属病院, 研修登録医
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 早産児 / MRI / 拡散テンソルMR画像 / MRスペクトロスコピー / 発達障害 / 拡散テンソル画像 / 三次元画像 |
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| Outline of Final Research Achievements |
The aim of the study was to elucidate the pathophysiological mechanisms causing the intellectual disabilities and behavioral abnormalities commonly noted in preterm infants. We performed diffusion tensor magnetic resonance (MR) imaging and MR spectroscopy on children at term-equivalent ages and compared the data to those of normal-term infants. We found that the preterm brain exhibited delayed maturation compared with the term brain. Additionally, delayed maturation detected by advanced MR imaging was associated with developmental outcomes at 18 months of age. Furthermore, delayed maturation was associated with an immature electroencephalographic pattern at term age. Thus, the brain maturation of preterm infants differed both structurally and functionally from that of term infants, in turn delaying developmental outcomes to at least 18 months of age.
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