Elucidation of structural and functional alterations of the preterm brain using advanced MR imaging
Project/Area Number |
26461543
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
早川 昌弘 名古屋大学, 医学部附属病院, 病院教授 (40343206)
夏目 淳 名古屋大学, 医学系研究科, 寄附講座教授 (60422771)
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Research Collaborator |
OGAWA Chikako 名古屋大学, 医学部附属病院, 研修登録医
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
Keywords | 早産児 / MRI / 拡散テンソルMR画像 / MRスペクトロスコピー / 発達障害 / 拡散テンソル画像 / 三次元画像 |
Outline of Final Research Achievements |
The aim of the study was to elucidate the pathophysiological mechanisms causing the intellectual disabilities and behavioral abnormalities commonly noted in preterm infants. We performed diffusion tensor magnetic resonance (MR) imaging and MR spectroscopy on children at term-equivalent ages and compared the data to those of normal-term infants. We found that the preterm brain exhibited delayed maturation compared with the term brain. Additionally, delayed maturation detected by advanced MR imaging was associated with developmental outcomes at 18 months of age. Furthermore, delayed maturation was associated with an immature electroencephalographic pattern at term age. Thus, the brain maturation of preterm infants differed both structurally and functionally from that of term infants, in turn delaying developmental outcomes to at least 18 months of age.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] phenotypes from infantile lethality to mild learning difficulties2017
Author(s)
Tanigawa J, Mimatsu H, Mizuno S, Okamoto N, Fukushi D, Tominaga K, Kidokoro H, Muramatsu Y, Nishi E, Nakamura S, Motooka D, Nomura N, Hayasaka K, Niihori T, Aoki Y, Nabatame S, Hayakawa M, Natsume J, Ozono K, Kinoshita T, Wakamatsu N, Murakami Y
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Journal Title
Human Mutation
Volume: 印刷中
Issue: 7
Pages: 805-815
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Paroxysmal nonepileptic events in children with epilepsy.2017
Author(s)
Ito Y, Kidokoro H, Negoro T, Tanaka M, Okai Y, Sakaguchi Y, Ogawa C, Takeuchi T, Ohno A, Yamamoto H, Nakata T, Maesawa S, Watanabe K, Takahashi Y, Natsume J
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Journal Title
Epilepsy Research
Volume: 132
Pages: 59-63
DOI
Related Report
Peer Reviewed
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[Journal Article] Preterm Brain Injury on Term-Equivalent Age MRI in relation to Perinatal Factors and Neurodevelopmental Outcome at Two Years2017
Author(s)
Margaretha J. Brouwer, Karina J. Kersbergen, Britt J.M. van Kooij, Linda S. De Vries, Manon J.N.L. Benders, Floris Groenendaal, Ingrid C. van Haastert, Corine Koopman-Esseboo, Terrie E. Inder, Jeffrey J. Neil, Hiroyuki Kidokoro
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Journal Title
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Primary psoas abscess caused by group A streptococcus in a child: Case report with microbiologic findings2016
Author(s)
Kamiya Y, Hasegawa T, Takegami Y, Horiba K, Ando S, Torii Y, Kidokoro H, Kato T, Natsume J, Kawada JI, Ito Y
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Journal Title
J Infect Chemother
Volume: 22
Issue: 12
Pages: 811-814
DOI
Related Report
Peer Reviewed
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[Journal Article] The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.2016
Author(s)
Takeuchi T, Natsume J, Kidokoro H, Ishihara N, Yamamoto H, Azuma Y, Ito Y, Kurahashi N, Tsuji T, Suzuki M, Itomi K, Yamada K, Kurahashi H, Abe S, Okumura A, Maruyama K, Negoro T, Watanabe K, Kojima S
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Journal Title
Brain Dev
Volume: 38
Issue: 8
Pages: 723-730
DOI
Related Report
Peer Reviewed
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[Journal Article] Rituximab treatment for relapsed opsoclonus-myoclonus syndrome.2016
Author(s)
Toyoshima D, Morisada N, Takami Y, Kidokoro H, Nishiyama M, Nakagawa T, Ninchoji T, Nozu K, Takeshima Y, Takada S, Nishio H, Iijima K
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Journal Title
Brain & Development
Volume: 38
Issue: 3
Pages: 346-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Increased fetal heart rate variability in periventricular leukomalacia.2016
Author(s)
Kurahashi H, Okumura A, Kubota T, Kidokoro H, Maruyama K, Hayakawa M, Itakura A, Matsuzawa K, Yamamoto H, Kato T, Hayakawa F, Watanabe K
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Journal Title
Brain & Development
Volume: 38
Issue: 2
Pages: 196-203
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clinical and neuroimaging findings in children with posterior reversible encephalopathy syndrome.2016
Author(s)
Yamamoto H, Natsume J, Kidokoro H, Ishihara N, Suzuki M, Tsuji T, Kubota T, Yamada A, Ozeki M, Kato Z, Kawamura Y, Yoshikawa T, Okumura A, Ando N, Saitoh S, Takahashi Y, Watanabe K, Kojima S.
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Journal Title
European Journal of Paediatric Neurology
Volume: 19
Issue: 6
Pages: 672-8
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] White Matter Abnormality Correlates with Developmental and Seizure Outcomes in West Syndrome of Unknown Etiology2015
Author(s)
Natsume J, Ogawa C, Fukasawa T, Yamamoto H, Ishihara N, Sakaguchi Y, Ito Y, Takeuchi T, Azuma Y, Ando N, Kubota T, Tsuji T, Kawai H, Naganawa S, Kidokoro H
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Journal Title
American Journal of Neuroradiology
Volume: 37
Issue: 4
Pages: 698-705
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Seizure characteristics of epilepsy in childhood after acute encephalopathy with biphasic seizures and late reduced diffusion.2015
Author(s)
Ito Y, Natsume J, Kidokoro H, Ishihara N, Azuma Y, Tsuji T, Okumura A, Kubota T, Ando N, Saitoh S, Miura K, Negoro T, Watanabe K, Kojima S.
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Journal Title
Epilepsia
Volume: 56
Issue: 8
Pages: 1286-93
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 先天性GPIアンカー欠損症の一女児に観察した発作時脳波記録2015
Author(s)
城所博之,伊藤祐史,小川千香子,大野敦子,竹内智哉,根来民子,夏目淳,渡辺一功,見松はるか,片岡英里奈,杉山裕一朗,鈴木俊彦,北瀬悠磨,松沢要,伊藤美春,齊藤明子,近藤大貴,村松友佳子,佐藤義朗,早川昌弘
Organizer
第71回名古屋臨床脳波検討会
Place of Presentation
安保ホール(愛知県名古屋市)
Year and Date
2015-10-10
Related Report
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[Presentation] EEG predicts delayed maturation on MRI at term in preterm infants2015
Author(s)
Ogawa C,Kidokoro H, Ito Y,Negoro T,Watanabe K, Sugiyama Y,Ito M,Sato Y, Hayakawa M,Natsume J
Organizer
The 9th international conference brain monitoring & neuroprotection in the newborn
Place of Presentation
Cork, Ireland
Year and Date
2015-10-02
Related Report
Int'l Joint Research
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