| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
As a pathophysiological analysis of the subacute sclerosing panencephalitis, which is intractable disease due to unknown pathophysiology, we planned the genetic analysis for identification of responsible gene and biological analysis for clarifying cellular mechanism using neurons differentiated from iPS cells and genetically modified measles virus.
For the exosome analysis, we analyzed 8 patients of 3 families, which had no consanguineous parentage. We performed analysis assuming the inheritance model as compound heterozygote, but failed to determine the responsible gene. We succeeded in establishing iPS cells from peripheral blood mononuclear cells of 3 patients with subacute sclerosing panencephalitis. There was no morphological difference between neurons differentiated from iPS cells derived from subacute sclerosing panencephalitis patients and those of from healthy control.
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