| Project/Area Number |
26461551
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
早川 昌弘 名古屋大学, 医学部附属病院, 病院教授 (40343206)
青木 茂樹 順天堂大学, 医学部, 教授 (80222470)
池野 充 順天堂大学, 医学部, 助教 (00567985)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 拡散MRI / 拡散カトーシス画像 / 拡散テンソル画像 / 微細構造 / 拡散カトーシス / fractional anisotropy / mean kurtosis / 中枢神経発達 / 早産児 |
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| Outline of Final Research Achievements |
We performed analyses of microstructural abnormalities of the brain in children with various neurological diseases by using next generation diffusion MRI imaging technique. By applying a 32-axis gradient magnetic field and 3 b values using a 3 Tesla MRI apparatus, we determined the protocol to obtain appropriate diffusion kurtosis images. We attempted to detect microstructural abnormalities of the brain in children with various neurological diseases by means of fractional anisotropy (FA) and mean kurtosis (MK) values as parameters. In particular, many cases of perinatal brain damage could be examined. As a result, there was a resolution limit in diffusion kurtosis images, and it became clear that its detection capability was insufficient. Statistical analysis by tract-based spatial statistics revealed that there is a correlation between MK values and neurological outcome.
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