• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Porimorfism of micro RNA in Japanese children with type 1 diabetes

Research Project

Project/Area Number 26461553
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionNihon University

Principal Investigator

URAKAMI Tatsuhiko  日本大学, 医学部, 准教授 (60223616)

Co-Investigator(Kenkyū-buntansha) 鈴木 潤一  日本大学, 医学部, 助教 (00573825)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords小児 / 1型糖尿病 / micro RNA / 発症機序 / 発症予防 / micro RNA多型 / 膵島関連自己抗体 / インスリン分泌能 / 遺伝子多型
Outline of Final Research Achievements

One hundred eighty seven children with type 1 diabetes, who showed positive for β-cell associated antibodies and exhausted endogenous insulin secretion, were studied. Using their stored DNA, we performed amplicon-based assay for targeted resequencing of the DNA, targeting the 69 candidate micro RNAs, with next generation sequencer. We conducted this procedure twice, however,the results were not provided, because of poor clustering or excessive clustering from DNA samples. It was impossible to perform the same procedure using the same DNA samples. We therefore evaluated association between clinical features and vivo expression of micro RNA in newly diagnosed patients with type 1 diabetes.However, we did not find significant association between dose of expression of miRNA and all the clinical features, including onset-age, onset- type of diabetes, presence of β-cell associated antibodies and residual β-cell function.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (42 results)

All 2018 2017 2016 2015 2014

All Journal Article (17 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 17 results,  Open Access: 17 results) Presentation (16 results) (of which Int'l Joint Research: 9 results,  Invited: 3 results) Book (9 results)

  • [Journal Article] New insights into the pharmacological treatment of pediatric patients with type 2 diabetes.2018

    • Author(s)
      Urakami T
    • Journal Title

      Clin Pediatr Endocrinol

      Volume: 27 Pages: 1-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased trend in the incidence of diabetes among youths in the USA during 2002-20122018

    • Author(s)
      Urakami T
    • Journal Title

      J diabetes Invest

      Volume: 8 Pages: 748-749

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Similalities and differences from type 2 diabetes in other pediatric populations2018

    • Author(s)
      Urakami T
    • Journal Title

      Curr Diab Rep

      Volume: 18 Issue: 6 Pages: 29-35

    • DOI

      10.1007/s11892-018-0999-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A randomized crossover study of the efficacy and safety of switching from insulin glargine to insulin degludec in children with type 1 diabetes2017

    • Author(s)
      Urakami T, Mine Y, Aoki M, Okuno M, Suzuki J
    • Journal Title

      Endocrine Journal

      Volume: 64 Issue: 2 Pages: 133-140

    • DOI

      10.1507/endocrj.EJ16-0294

    • NAID

      130005397069

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvement in glycemic control through changes in insulin regimens: findings from a Japanese cohort of children and adolescents with type 1 diabetes2017

    • Author(s)
      128.Mochizuki M, Kikuchi T, Urakami T, Kikuchi N, Kawamura T, Yokomichi H, Hoshino T, Matsuura N, Sasaki N, Sugihara S, Amemiya S, on behalf of The Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT)
    • Journal Title

      Pediatr Diabeets

      Volume: 18 Pages: 435-444

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Education activities inmrove detection of growrh abnormalities in young children.2016

    • Author(s)
      Urakami T, Nishimura K, Nishimura Y, Takahashi S
    • Journal Title

      Pediatric International

      Volume: 58 Pages: 1255-1256

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of monogenic gene mutations in Japanese subjects diagnosed with type 1B diabetes between >5 and 15.1 years of age.2016

    • Author(s)
      Moritani M, Yokota I, Horikawa R, Urakami T, Nishii A, Kawamura T, Kikuchi N, Kikuchi T, Ogata T, Sugihara S
    • Journal Title

      J Pediatr Endocrinol Metab

      Volume: 29 Pages: 1047-1054

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of switching from insulin glargine to insulin degludec in young people with type 1 diabetes2016

    • Author(s)
      Urakami T, Kuwabara R, Aoki M, Okuno M, Suzuki J
    • Journal Title

      Endocrine Journal

      Volume: 63 Issue: 2 Pages: 159-167

    • DOI

      10.1507/endocrj.EJ15-0245

    • NAID

      130005127188

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The ratio of glycated albumin to hemoglobin A1c measured in IFCC units accurately represents the glycation gap2015

    • Author(s)
      Akatsuka J, Mochizuki M, Musha I, Ohtake A, Kobayashi K, Kikuchi T, Kikuchi N, Kawamura T, Urakami T, Sugihara S, Hoshino T, Amemiya S
    • Journal Title

      Endocr J

      Volume: 62 Pages: 161-172

    • NAID

      130004704362

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 小児期発症1型糖尿病の糖尿病性ケトアシドーシスと重症低血糖に関する検討-CSII使用に関する問題点を考える2015

    • Author(s)
      青木政子、鈴 木潤一、浦上達彦
    • Journal Title

      日本先進糖尿病治療研究会雑誌

      Volume: 10 Pages: 21-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three years of liraglutide treatment offers continuously optimal glycemic control in a pediatric patients with maturity-onset diabetes of the young type 32015

    • Author(s)
      Urakami T, Habu M, Okuno M, Suzuki J, Takahashi S, Yorifuji T
    • Journal Title

      J Pediatr Endocrinol Metab

      Volume: 28 Pages: 327-331

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] diabetesEfficacy and safety of switching to insulin glulisine from other rapid-acting insulin analogues in children with type 1 diabetes2015

    • Author(s)
      Urakami T, Kuwabara R, Habu M, Okuno M, Suzuki J, Takahashi S
    • Journal Title

      J Diabetes Invest

      Volume: 6 Pages: 87-90

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Basal insulin requirement of youth with type 1 diabetes differs according to age2014

    • Author(s)
      .Urakami T, Kuwabara R, Habu M, Okuno M, Suzuki J, Takahashi S
    • Journal Title

      J Diabetes Invest

      Volume: 5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin glargine in pediatric patients with type 1 diabetes in Japan2014

    • Author(s)
      Urakami T, Naito Y, Seino Y
    • Journal Title

      Pediatr In

      Volume: 56

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation spectrum and phenotypic variation in nine patients with SOX2 abnormalities2014

    • Author(s)
      Suzuki J, Azuma N, Dateki S, Soneda S, Muroya K, Yamamoto Y, Saito R, Sano S, Nagai T, Wada H, Endo A, Urakami T, Ogata T, Fukami M
    • Journal Title

      J Hum Genet

      Volume: 59

    • NAID

      40020109446

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential for BIAsp 70 to control postprandial hyperglycemia in children with type 1 diabetes2014

    • Author(s)
      Urakami T, Kuwabara R, Habu M, Komiya K, Suzuki J, Takahashi S
    • Journal Title

      J Ninon Univ Med Asso

      Volume: 73

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] DKA and severe hypoglycemia in management of type 1 diabetes during 2003-20132014

    • Author(s)
      Urakami T, Habu M, Suzuki J
    • Journal Title

      Pediatr Int

      Volume: 56 Issue: 6 Pages: 940-940

    • DOI

      10.1111/ped.12521

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Change in annual incidence of childhood type 2 diabetes detected by urine glucose screening at schools in the Tokyo Metropolitan area during 1975-20152017

    • Author(s)
      T. Urakami, M. Yoda, K. Yoshida, S. Tanabe, Y. Mine, M. Aoki, J. Suzuki
    • Organizer
      43th ISPAD Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biochemical characteristics of diabetic ketoacidosis in Japanese type 1 diabetes treated with insulin analogues2017

    • Author(s)
      J. Suzuki, K. Yoshida, S. Tanabe, Y. Mine, M. Aoki, T. Urakami
    • Organizer
      43th ISPAD Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of coenzyme Q10 treatment in a case of young woman with mitochondrial diabetes mellitus2017

    • Author(s)
      M. Habu, S. Tanabe, Y. Mine, J. Suzuki, T. Urakami
    • Organizer
      43th ISPAD Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of glucagon test in children with acute-onset type 1 diabetes2017

    • Author(s)
      K. Yoshida, M. Yoda, S. Takahashi, Y. Mine, S. Tanabe, M. Aoki, J. Suzuki, T. Urakami, S. Takahashi.
    • Organizer
      43th ISPAD Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ChildhrenNucleotide substitutions in CD101, the human homolog of diabetes susceptibility gene in non-obese diabetic mouse, in patients with type 1 diabetes mellitus2017

    • Author(s)
      M. Okuno, Y. Kasahara, N. Takubo, M. Okajima, S. Suga, J. Suzuki, T. Ayabe, T. Urakami, T. Kawamura, N. Kikuchi, I. Yokota, T. Kikuchi, S. Amemiya, T. Ogata, M. Fukami, S. Sugihara, Japanese Study Group of Insulin Therapy for
    • Organizer
      43th ISPAD Annual meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clinical characteristics in schoolchildren with renal glucosuria detected by urine glucose screening program at schools in Tokyo metropolitan area during 2000-2015.2016

    • Author(s)
      Urakami T, Mine Y, Aoki M, Okuno M, Suzuki J.
    • Organizer
      50th Annual meeting for the Japanese Society for Pediatric Endocrinology/9th Biannual meeting for Asia Pacific Pediatric Endocrine Society
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 糖尿病眼合併症に対する治療継続のために―小児・若年糖尿病の眼合併症2015

    • Author(s)
      浦上達彦
    • Organizer
      第21回日本糖尿病眼学会総会
    • Place of Presentation
      愛知県産業労働センターウインク愛知, 愛知県 名古屋市
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] . A randomized crossover study of the efficacy and safety of switching from insulin glargine to insulin degludec in children with type 1 diabetes2015

    • Author(s)
      Urakami T, Kuwabara R, Mine Y, Aoki M, Okuno M, Suzuki J
    • Organizer
      7th AASD Scientific Meeting of the Hong Kong Society of Endocrinology, Metabolism and Reproduction
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 小児1型糖尿病の血糖自己管理と心理・社会的問題2015

    • Author(s)
      浦上達彦
    • Organizer
      第33回日本小児心身医学会学術集会
    • Place of Presentation
      国際オリンピック記念青少年総合センター, 東京都 渋谷区
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] A randomized crossover study of the efficacy and safety of switching from insulin glargine to insulin degludec in children with type 1 diabetes2015

    • Author(s)
      Urakami T, Kuwabara R, Mine Y, Aoki M, Okuno M, Suzuki J
    • Organizer
      75th scientific sessions of American Diabetes Association
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] DKA and severe hypoglycemia in management of type 1 diabetes during 2003-20132015

    • Author(s)
      Urakami T, Mine Y, Aoki M, Suzuki J
    • Organizer
      PAS/ASPR/JPS Joint Session 1. 第88回日本小児科学会学術集会
    • Place of Presentation
      大阪国際会議場, 大阪府 大阪市
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficacy of insulin degludec after switching from insulin glargine or insulin detemir in young persons with type 1 diabetes.2014

    • Author(s)
      Urakami T, Mine Y, Aoki M, Okuno M, Suzuki J
    • Organizer
      10th IDF-WPR Congress
    • Place of Presentation
      Singapore (Singapore)
    • Year and Date
      2014-11-24 – 2014-11-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 小児1型糖尿病に対するインスリンデグルデクの有効性・安全性に関する検討2014

    • Author(s)
      浦上達彦、峯 佑介、桑原怜未、青木政子、奥野美佐子、鈴木潤一
    • Organizer
      第48回日本小児内分泌学会
    • Place of Presentation
      アクトシティ浜松 (静岡県・浜松市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Treatment of type 1 diabetes in Japan2014

    • Author(s)
      Urakami T
    • Organizer
      2014 Pedi-Endo Symposium
    • Place of Presentation
      Taioei (Taiwan)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Efficacy of insulin degludec as basal-bolus therapy after switching from insulin glargine or insulin detemir in young persons with type 1 diabetes2014

    • Author(s)
      Urakami T, Habu M, Okuno M, Suzuki J, Takahashi S
    • Organizer
      74th Scientific Sessions of American Diabetes Association
    • Place of Presentation
      Sanfransisco (USA)
    • Year and Date
      2014-06-13 – 2014-06-17
    • Related Report
      2014 Research-status Report
  • [Presentation] CSIIにおけるグルリジンのresponderとnon-responderの比較2014

    • Author(s)
      浦上達彦、羽生政子、奥野美佐子、鈴木潤一、高橋昌里
    • Organizer
      .第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場 (大阪府・大阪市)
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 糖尿病治療の手びき 2017. 改訂第57版2017

    • Author(s)
      浦上達彦
    • Total Pages
      250
    • Publisher
      南江堂
    • Related Report
      2017 Annual Research Report
  • [Book] 小児・思春期1型糖尿病の診療ガイド2017

    • Author(s)
      浦上達彦
    • Total Pages
      95
    • Publisher
      南江堂
    • Related Report
      2017 Annual Research Report
  • [Book] 改訂第7版. 小児糖尿病. 糖尿病専門医研修ガイドブック2017

    • Author(s)
      浦上達彦
    • Total Pages
      323
    • Publisher
      診断と治療社
    • Related Report
      2017 Annual Research Report
  • [Book] 代謝性疾患, 栄養障害-2型糖尿病. 今日の小児治療指針. 第16版. 総編集 水口 雅, 市橋 光, 崎山 弘2015

    • Author(s)
      浦上達彦
    • Total Pages
      783
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report
  • [Book] 小児科疾患. 小児の肥満. 今日の治療指針 20162015

    • Author(s)
      浦上達彦
    • Total Pages
      2096
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report
  • [Book] 小児・思春期の糖尿病. 糖尿病最新の治療 2016-2018 編集 羽田勝計、門脇 孝、荒木栄一2015

    • Author(s)
      峯 佑介、浦上達彦
    • Total Pages
      879
    • Publisher
      南江堂
    • Related Report
      2015 Research-status Report
  • [Book] 内分泌・代謝疾患. 糖尿病. 小児科診療ガイドライン-最新の診療指針― 第3版. 編集 五十嵐 隆2015

    • Author(s)
      浦上達彦
    • Total Pages
      289
    • Publisher
      総合医学社
    • Related Report
      2015 Research-status Report
  • [Book] ビギナーのための小児内分泌ガイド2014

    • Author(s)
      浦上達彦,桑原怜未
    • Publisher
      中山書店
    • Related Report
      2014 Research-status Report
  • [Book] 糖尿病研修ノート. 改訂第2版2014

    • Author(s)
      浦上達彦
    • Publisher
      診断と治療社
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi