Study for a development of a treatment of ASD with a clomosome duplicated ASD model mouse.
| Project/Area Number |
26461554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 秀典 日本医科大学, 大学院医学研究科, 大学院教授 (30221328)
齋藤 文仁 日本医科大学, 医学部, 准教授 (20360175)
坂井 敦 日本医科大学, 医学部, 講師 (30386156)
三ケ原 靖規 日本医科大学, 医学部, アシスタントスタッフ (20748636)
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| Co-Investigator(Renkei-kenkyūsha) |
Takumi Toru 理化学研究所, 脳科学総合研究センター, 教授 (00222092)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 自閉症 / 社会性 / セロトニン / 背側縫線核 / オキシトシン / セロトニン1A受容体 |
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| Outline of Final Research Achievements |
We investigated a way of treatment for ASD by using a chromosome duplicated ASD model mouse (15q-dup).
Because the serotonin content in the brain of 15q-dup mouse was decreased from neonatal period, we tried a treatment with a selective serotonin re-uptake inhibitor, fluoxetine, during 3 weeks after birth. The lower sociability and brain 5-HT level were ameliorated in adult 15q-dup mice, but their persistent behavior and repetitive behavior were not. Electrophysiological experiments revealed that 5-HT neurons had more hyperpolarized resting membrane potentials and smaller excitatory glutamatergic inputs in the dosal raphe nucleus in 15q-dup mice compared with the wildtype. In association with the serotonin restoration, neonatal FLX treatment also ameliorated these electrophysiological of 15q-dup mice. （Science Advances, in press）
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Report
(4 results)
Research Products
(4 results)
