| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The effects of circadian clock system in the regulatin of bone metabolism was investigated using mice lacking Bmal1, a core clock gene, in the intestine (cKO mice). cKO mice displayed impaired Calcium (Ca) absorption associated with elevations in PTH levels. Mechanistically, VDR showed rhythmic transcriptional pattern in the intestine, and this was dissapeared in cKO mice. Skeletal phentyping of cKO mice revealed decreases in bone mass associated with enhanced bone resorption. additionally, decreased bone mass was not observed when mice were fed with high Ca diet. Collectively, these findings suggest that circadian clock system in the intestine regulates bone metabolism by fine-tuning Ca absorption.
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