• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Biennial epidemics and clinical features of influenza C virus infections.

Research Project

Project/Area Number 26461563
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionYamagata University

Principal Investigator

Matsuzaki Yoko  山形大学, 医学部, 准教授 (00292417)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsC型インフルエンザウイルス / 抗原変異 / 抗体保有率 / 小児肺炎 / 遺伝子進化 / 肺炎
Outline of Final Research Achievements

Epidemics of influenza C virus infection occurred in Yamagata, in 2014 and 2016, but we could not detect antigenic changes of viruses during a study period. Annual investigation of seroprevalence revealed that the prevalence of the antibodies against influenza C virus in 2015 and 2017 were similar to those in 2014 and 2016, suggesting that influenza C virus had been circulating asymptomatically in 2015 and 2017. Influenza C virus infections in a hospital setting had similar rate of pneumonia, significantly lower frequency of wheezing, and higher levels of WBC and C-reactive protein than human metapneumovirus (hMPV) infection, suggesting that bacterial coinfections make respiratory conditions more severe.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (7 results)

  • [Journal Article] Clinical characteristics of children infected with enterovirus D68 in an outpatient clinic and the association with bronchial asthma2018

    • Author(s)
      Itagaki Tsutomu、Aoki Yoko、Matoba Yohei、Tanaka Shizuka、Ikeda Tatsuya、Mizuta Katsumi、Matsuzaki Yoko
    • Journal Title

      Infectious Diseases

      Volume: 50 Issue: 4 Pages: 303-312

    • DOI

      10.1080/23744235.2017.1400176

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of Saffold viruses from children with acute respiratory infections in Yamagata, Japan, between 2008 and 20152018

    • Author(s)
      Itagaki Tsutomu、Aoki Yoko、Matoba Yohei、Tanaka Shizuka、Ikeda Tatsuya、Matsuzaki Yoko、Mizuta Katsumi
    • Journal Title

      Journal of Medical Virology

      Volume: 90 Issue: 1 Pages: 34-40

    • DOI

      10.1002/jmv.24928

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014.2016

    • Author(s)
      Matsuzaki Y, Sugawara K, Furuse Y, Shimotai Y, Hongo S, Oshitani H, Mizuta K, Nishimura H.
    • Journal Title

      J Virol.

      Volume: 90 Issue: 18 Pages: 8251-8265

    • DOI

      10.1128/jvi.00969-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses.2016

    • Author(s)
      Furuse Y, Matsuzaki Y, Nishimura H, Oshitani H.
    • Journal Title

      Viruses

      Volume: 8 Issue: 12 Pages: 321-321

    • DOI

      10.3390/v8120321

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Influenza C virus and human metapneumovirus infections in hospitalized children with lower respiratory tract illness.2015

    • Author(s)
      Shimizu Y, Abiko C, Ikeda T, Mizuta K, Matsuzaki Y
    • Journal Title

      Pediatric Infectious Disease Journal

      Volume: 34 Issue: 11 Pages: 1273-1275

    • DOI

      10.1097/inf.0000000000000863

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The Dominant Antigenic Group of Influenza C Infections Changed from C/Sao Paulo/378/82-Lineage to C/Kanagawa/1/76-Lineage in Yamagata, Japan, in 20142015

    • Author(s)
      Tanaka S, Aoki Y, Matoba Y, Yahagi K, Mizuta K, Itagaki T, Katsushima F, Katsushima Y, Matsuzaki Y.
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 68 Issue: 2 Pages: 166-168

    • DOI

      10.7883/yoken.JJID.2014.520

    • NAID

      130004757144

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 2015-16シーズンのC型インフルエンザの流行.2017

    • Author(s)
      松嵜葉子,下平義隆,本郷誠治,水田克巳,西村秀一
    • Organizer
      第31回インフルエンザ研究者交流の会シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 岩手県で検出されたC型インフルエンザウイルスの性状解析.2017

    • Author(s)
      高橋雅輝, 小原崇裕, 松嵜葉子, 佐々木裕, 吉野直人, 梶田弘子, 小野泰司, 村木 靖
    • Organizer
      第71回日本細菌学会東北支部総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] C型インフルエンザウイルスHEタンパクの開裂に関わる宿主プロテアーゼの解析.2017

    • Author(s)
      佐藤光,林日出喜,下平義隆,松嵜葉子,山谷睦雄,本郷誠治,川上和義,西村秀一
    • Organizer
      第71回日本細菌学会東北支部総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Analysis of host serine proteases involved in cleavage of HE protein of the influenza C virus.2017

    • Author(s)
      Sato K, Hayashi H, Shimotai Y, Matsuzaki Y, Yamaya M, Hongo S, Kawakami K, Nishimura H
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エンテロウイルスD68感染症の2シーズン(2010年と2015年)の臨床的検討.2016

    • Author(s)
      松嵜葉子,板垣勉
    • Organizer
      日本小児感染症学会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Year and Date
      2016-11-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 2014年のC型インフルエンザウイルスの流行2015

    • Author(s)
      松嵜葉子,菅原勘悦,下平義隆,本郷誠治,水田克巳,西村秀一
    • Organizer
      第29回インフルエンザ研究者交流の会
    • Place of Presentation
      東京大学医科学研究所(東京都港区)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Research-status Report
  • [Presentation] 2014年山形県におけるC型インフルエンザウイルスの分離状況2015

    • Author(s)
      田中静佳,的場洋平,青木洋子,矢作一枝,水田克巳,勝島史夫,勝島由利子,板垣勉,松嵜葉子
    • Organizer
      第41回山形県公衆衛生学会
    • Place of Presentation
      山形県立保健医療大学(山形市)
    • Year and Date
      2015-03-05
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi