Biennial epidemics and clinical features of influenza C virus infections.

• Project/Area Number: 26461563
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Yamagata University
• Principal Investigator: Matsuzaki Yoko 山形大学, 医学部, 准教授 (00292417)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: C型インフルエンザウイルス / 抗原変異 / 抗体保有率 / 小児肺炎 / 遺伝子進化 / 肺炎

Outline of Final Research Achievements

Epidemics of influenza C virus infection occurred in Yamagata, in 2014 and 2016, but we could not detect antigenic changes of viruses during a study period. Annual investigation of seroprevalence revealed that the prevalence of the antibodies against influenza C virus in 2015 and 2017 were similar to those in 2014 and 2016, suggesting that influenza C virus had been circulating asymptomatically in 2015 and 2017. Influenza C virus infections in a hospital setting had similar rate of pneumonia, significantly lower frequency of wheezing, and higher levels of WBC and C-reactive protein than human metapneumovirus (hMPV) infection, suggesting that bacterial coinfections make respiratory conditions more severe.

Research Products

• [Journal Article] Clinical characteristics of children infected with enterovirus D68 in an outpatient clinic and the association with bronchial asthma (2018)
  • Author(s): Itagaki Tsutomu、Aoki Yoko、Matoba Yohei、Tanaka Shizuka、Ikeda Tatsuya、Mizuta Katsumi、Matsuzaki Yoko
  • Journal Title: Infectious Diseases Volume: 50 Issue: 4 Pages: 303-312
  • DOI: 10.1080/23744235.2017.1400176
  • Peer Reviewed
• [Journal Article] Detection of Saffold viruses from children with acute respiratory infections in Yamagata, Japan, between 2008 and 2015 (2018)
  • Author(s): Itagaki Tsutomu、Aoki Yoko、Matoba Yohei、Tanaka Shizuka、Ikeda Tatsuya、Matsuzaki Yoko、Mizuta Katsumi
  • Journal Title: Journal of Medical Virology Volume: 90 Issue: 1 Pages: 34-40
  • DOI: 10.1002/jmv.24928
  • Peer Reviewed
• [Journal Article] Genetic Lineage and Reassortment of Influenza C Viruses Circulating between 1947 and 2014. (2016)
  • Author(s): Matsuzaki Y, Sugawara K, Furuse Y, Shimotai Y, Hongo S, Oshitani H, Mizuta K, Nishimura H.
  • Journal Title: J Virol. Volume: 90 Issue: 18 Pages: 8251-8265
  • DOI: 10.1128/jvi.00969-16
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses. (2016)
  • Author(s): Furuse Y, Matsuzaki Y, Nishimura H, Oshitani H.
  • Journal Title: Viruses Volume: 8 Issue: 12 Pages: 321-321
  • DOI: 10.3390/v8120321
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Influenza C virus and human metapneumovirus infections in hospitalized children with lower respiratory tract illness. (2015)
  • Author(s): Shimizu Y, Abiko C, Ikeda T, Mizuta K, Matsuzaki Y
  • Journal Title: Pediatric Infectious Disease Journal Volume: 34 Issue: 11 Pages: 1273-1275
  • DOI: 10.1097/inf.0000000000000863
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Dominant Antigenic Group of Influenza C Infections Changed from C/Sao Paulo/378/82-Lineage to C/Kanagawa/1/76-Lineage in Yamagata, Japan, in 2014 (2015)
  • Author(s): Tanaka S, Aoki Y, Matoba Y, Yahagi K, Mizuta K, Itagaki T, Katsushima F, Katsushima Y, Matsuzaki Y.
  • Journal Title: Japanese Journal of Infectious Diseases Volume: 68 Issue: 2 Pages: 166-168
  • DOI: 10.7883/yoken.JJID.2014.520
  • NAID: 130004757144
  • ISSN: 1344-6304, 1884-2836
  • Peer Reviewed / Open Access
• [Presentation] 2015-16シーズンのC型インフルエンザの流行． (2017)
  • Author(s): 松嵜葉子，下平義隆，本郷誠治，水田克巳，西村秀一
  • Organizer: 第31回インフルエンザ研究者交流の会シンポジウム
• [Presentation] 岩手県で検出されたC型インフルエンザウイルスの性状解析. (2017)
  • Author(s): 高橋雅輝, 小原崇裕, 松嵜葉子, 佐々木裕, 吉野直人, 梶田弘子, 小野泰司, 村木 靖
  • Organizer: 第71回日本細菌学会東北支部総会
• [Presentation] C型インフルエンザウイルスHEタンパクの開裂に関わる宿主プロテアーゼの解析． (2017)
  • Author(s): 佐藤光，林日出喜，下平義隆，松嵜葉子，山谷睦雄，本郷誠治，川上和義，西村秀一
  • Organizer: 第71回日本細菌学会東北支部総会
• [Presentation] Analysis of host serine proteases involved in cleavage of HE protein of the influenza C virus. (2017)
  • Author(s): Sato K, Hayashi H, Shimotai Y, Matsuzaki Y, Yamaya M, Hongo S, Kawakami K, Nishimura H
  • Organizer: 第65回日本ウイルス学会学術集会
• [Presentation] エンテロウイルスD68感染症の2シーズン（2010年と2015年）の臨床的検討． (2016)
  • Author(s): 松嵜葉子，板垣勉
  • Organizer: 日本小児感染症学会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Year and Date: 2016-11-19
• [Presentation] 2014年のC型インフルエンザウイルスの流行 (2015)
  • Author(s): 松嵜葉子，菅原勘悦，下平義隆，本郷誠治，水田克巳，西村秀一
  • Organizer: 第29回インフルエンザ研究者交流の会
  • Place of Presentation: 東京大学医科学研究所（東京都港区）
  • Year and Date: 2015-05-22
• [Presentation] 2014年山形県におけるC型インフルエンザウイルスの分離状況 (2015)
  • Author(s): 田中静佳，的場洋平，青木洋子，矢作一枝，水田克巳，勝島史夫，勝島由利子，板垣勉，松嵜葉子
  • Organizer: 第41回山形県公衆衛生学会
  • Place of Presentation: 山形県立保健医療大学（山形市）
  • Year and Date: 2015-03-05