| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We investigated serum cytokine profile in patients with systemic juvenile idiopathic arthritis (s-JIA) and adult onset Still’s disease (AOSD). Furthermore, we sequentially analyzed NK cell activation upon IL-18 in these patients from active phase to remisson. Serum IL-18 levels were extremely elevated in s-JIA and AOSD patients. IL-6 dominant subset was prone to arthritis, while IL-18 dominant subset was prone to develop macrophage activation syndrome (MAS). NK cell activation upon IL-18 was impaired in active phase and recovered after treatment as serum IL-18 levels decreased. Extensive cytokine profile analysis with antibody array revealed IL-18/IFNγ axis play a key role to develop MAS.
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