Serum microRNAs as potential biomarkers of juvenile idiopathic arthritis
Project/Area Number |
26461578
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | Nagoya University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
伊藤 嘉規 名古屋大学, 医学系研究科, 准教授 (20373491)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 若年性特発性関節炎 / マイクロRNA |
Outline of Final Research Achievements |
MicroRNAs (miRNAs) are non-coding RNAs, and may have the potential to serve as biomarkers of disease. We evaluated serum levels of selected miRNAs and their associations with disease activity in juvenile idiopathic arthritis (JIA). Sera and peripheral blood leukocytes were collected from patients with JIA and healthy controls. Levels of miR-16, miR-132, miR-146a, miR-155, and miR-223 were quantified. Levels of miR-223 in sera were significantly higher in patients in the active phase of systemic onset JIA than in controls. In both systemic onset JIA and polyarthritis patients, levels of miR-223 and miR-16 correlated with erythrocyte sedimentation rate and matrix metalloproteinase-3, respectively. MiR-146a and miR-223 in polyarthritis showed correlation with matrix metalloproteinase-3. Expressions of miRNAs were altered in patients with JIA. Serum levels of miR-223 may be potential disease biomarkers. These findings may shed light on the pathogenesis of JIA.
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Report
(4 results)
Research Products
(50 results)
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Ando S, Kawada J, Watanabe T, Suzuki M, Sato Y, Torii Y, Asai M, Goshima F, Murata T, Shimizu N, Ito Y, Kimura H
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Issue: 4
Pages: 359-367
DOI
NAID
ISSN
2186-3326
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Journal Title
Frontiers in microbiology
Volume: 6
Pages: 280-280
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[Journal Article] mTOR Inhibitors Induce Cell Cycle Arrest and Inhibit Tumor Growth in Epstein-Barr Virus-Associated T and Natural Killer Cell Lymphoma Cells2014
Author(s)
Kawada, J., Ito, Y., Iwata, S., Suzuki, M., Kawano, Y., Kanazawa, T., Siddiquey, M.N., Kimura, H
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Journal Title
Clinical cancer research
Volume: 20
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Pages: 5412-22
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[Presentation] 抗胸腺グロブリンによる in vivo T細胞除去同種造血幹細胞移植を受けた小児におけるEBウイルス感染症に対するリツキシマブによる先制治療2016
Author(s)
濱麻人, 高橋義行, 伊藤嘉規, 川田潤一, 村上典寛, 谷口理恵子, 小島大英, 鈴木喬悟, 関屋由子, 川島希, 西川英里, 成田敦, 亀井美智, 村松秀城, 西尾信博, 小島勢二
Organizer
第38回日本造血細胞移植学会
Place of Presentation
名古屋国際会議場(愛知県名古屋市)
Year and Date
2016-03-03
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[Presentation] 名古屋大学小児科関連施設での院内蘇生症例の解析2015
Author(s)
大萱 俊介, 沼口 敦, 伊藤 祥絵, 田上 和憲, 羽田野 ちひろ, 宮地 悠江, 川田 潤一, 夏目 淳, 小島 勢二
Organizer
第118回日本小児科学会
Place of Presentation
大阪国際会議場(大阪府吹田市)
Year and Date
2015-04-17
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