| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Influenza-associated encephalopathy and human herpesvirus 6 encephalopathy are common forms of acute encephalitis/encephalopathy in Japan. Comprehensive metabolome profiling, which can analyze around 3,000 metabolites, was applied to discover new aspects of its disease pathophysiology and new potential biomarkers.
As a result of metabolome profiling, kynurenine and quinolinic acid were selected as potential metabolites associated with the pathophysiology of those two encephalopathies. Trans-endothelial electrical resistance of the in vitro blood brain barrier model was significantly decreased after quinolinic acid treatment in culture.
|
