Development new immunotherapy for pediatric cancer using human iPSCs

Research Project

Project/Area Number	26461583
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Pediatrics
Research Institution	Osaka University
Principal Investigator	Miyamura Takako 大阪大学, 医学系研究科, 助教 (20379796)
Co-Investigator(Kenkyū-buntansha)	橋井佳子大阪大学, 医学系研究科, 講師 (60343258) 北畠康司大阪大学, 医学部附属病院, 講師 (80506494)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	iPS細胞 / ガン免疫療法 / がんワクチン療法 / ゲノム編集 / 免疫療法 / がん免疫療法 / ゲノム編集技術
Outline of Final Research Achievements	We aimed to develop more efficient immunotherapy for pediatric cancer, using WT1 cancer vaccines and human iPSCs. We established the method to generate iPSCs more efficiently using Sendai virus.In addition, we developed oral cancer vaccine method using Bifidobacterium longum displaying WT1 protein.

Report

(4 results)